| dc.creator | Antoniolli, Ângelo Roberto | |
| dc.creator | Miranda, Fábio Guilherme Gonçalves de | |
| dc.creator | Vilar, Jeane Carvalho | |
| dc.creator | Alves, Ivana Andréa Nunes | |
| dc.creator | Cavalcanti, Sócrates Cabral de Holanda | |
| dc.date | 2014-09-17T18:02:50Z | |
| dc.date | 2014-09-17T18:02:50Z | |
| dc.date | 2001-09-13 | |
| dc.date.accessioned | 2023-09-28T22:36:44Z | |
| dc.date.available | 2023-09-28T22:36:44Z | |
| dc.identifier | MIRANDA, F. G. G. et al. Antinociceptive and antiedematogenic properties and acute toxicity of Tabebuia avellanedae Lor. ex Griseb. inner bark aqueous extract. BMC Pharmacol, v. 1, n. 6, 2001. Disponível em: <http://dx.doi.org/ 10.1186/1471-2210-1-6>. Acesso em: 17 set. 2014. | |
| dc.identifier | 1471-2210 | |
| dc.identifier | https://ri.ufs.br/handle/riufs/1204 | |
| dc.identifier | Copyright © 2001 de Miranda et al; licensee BioMed Central Ltd. | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9073446 | |
| dc.description | Background: Tabebuia avellanedae is a tree from the Bignoniaceae family. Commonly know as
"pau d'arco" in Brazil, its inner bark is used as analgesic, anti-inflammatory, antineoplasic and
diuretic at the Brazilian northeast. A validation of the plant usage has not been previously
performed.
Results: Antinociceptive and antiedematogenic effects of Tabebuia avellanedae Lor. ex Griseb. inner
bark were measured by nociceptive experimental models in mice. A rat paw edema test induced
by carrageenan (1%) was also performed in rats to access the plant's antiedematogenic effect. The
inner bark aqueous extract, administered via oral in three different concentration, namely 100, 200
and 400 mg/Kg, reduced the nociception produced by acetic acid (0.6% in water, i.p.) by 49.9%,
63.7% and 43.8%, respectively. The aqueous extract (200 and 400 mg/Kg, p.o.) reduced formalin
(1%) effects only at the second phase of the experiment by 49.3% and 53.7%, respectively.
Naloxone (5 mg/Kg, i.p.) was not able to revert the extract effect, however caffeine (10 mg/Kg, i.p.)
reverted its effect by 19.8% at the second phase of the formalin test. The aqueous extract (200 mg/
Kg, p.o.) inhibited edema by 12.9% when we used the rat paw edema model. The acute toxicity was
low in mice.
Conclusion: The T. avellanedae inner bark aqueous extract presented antinociceptive and
antiedematogenic activities at the used models, with a possible antinociceptive effect associated to
the adenosine system. | |
| dc.format | application/pdf | |
| dc.language | en | |
| dc.publisher | BioMed Central Ltd. | |
| dc.subject | Tabebuia avellanedae Lor. ex Griseb. | |
| dc.subject | Antinociceptivo | |
| dc.subject | Efeito antiedematogênico | |
| dc.title | Antinociceptive and antiedematogenic properties and acute toxicity of Tabebuia avellanedae Lor. ex Griseb. inner bark aqueous extract | |
| dc.type | Artigo | |
