Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach

dc.creatorVenâncio, Antônio Medeiros
dc.creatorMarchioro, Murilo
dc.creatorEstevam, Charles dos Santos
dc.creatorMelo, Mônica Santos de
dc.creatorSantana, Marília Trindade de
dc.creatorOnofre, Alexandre Sherlley Casimiro
dc.creatorGuimarães, Adriana Gibara
dc.creatorOliveira, Makson Gleydson Brito de
dc.creatorAlves, Péricles Barreto
dc.creatorPimentel, Hugo de Carvalho
dc.creatorQuintans-Júnior, Lucindo José
dc.date2013-06-08T12:45:41Z
dc.date2013-06-08T12:45:41Z
dc.date2011-08
dc.date.accessioned2023-09-28T22:36:03Z
dc.date.available2023-09-28T22:36:03Z
dc.identifierVENANCIO, Antônio M. et al. Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach. Revista Brasileira de Farmacognosia, Curitiba, v. 21, n. 6, dez. 2011 . Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000600015&lng=en&nrm=iso>. Acesso em: 8 jun. 2013.
dc.identifier0102-695X
dc.identifierhttps://ri.ufs.br/handle/riufs/595
dc.identifierCreative Commons Attribution License
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9073150
dc.descriptionThe present study investigated the antinociceptive effects of Ocimum basilicum L. (Lamiaceae) leaf essential oil (LEO) and (-)-linalool (LIN) in formalin (2%)-, glutamate (25 µM)- and capsaicin (2.5 µg)- induced orofacial nociception models in mice. The involvement of these substances was further evaluated on the neuronal excitability of the hippocampal dentate gyrus. Male mice (n=8/group) were pretreated separately with LEO and by LIN (50, 100, and 200 mg/kg, i.p.), morphine (5 mg/kg, i.p.) and vehicle (saline + Tween 80 0.2%), before injection of nociceptive agent into the right upper lip (perinasal area). The LEO and LIN reduced the nociceptive face-rubbing behaviour in both phases on formalin test. LEO and LIN, at high doses, produced significantly antinociceptive effect in the capsaicin and glutamate tests. In hippocampal slices, LEO inhibited the population spike generated by stimulation of the hylus (antidromic stimulation), with an IC50 of 0.1±0.05 mg/mL. This response was reversibly blocked by lidocaine (0.5 mg/mL), a known voltage-dependent sodium channel antagonist and by LIN (0.5 mg/mL). Our results suggest that LEO and LIN modulate neurogenic and inflammatory pain in the tests of orofacial nociception induced by formalin, capsaicin and glutamate. Part of these effects may be associated with decreased peripheral and central neuronal excitability.
dc.formatapplication/pdf
dc.languageen
dc.subjectÓleos essenciais
dc.subjectLinalol
dc.subjectManjericão
dc.subjectOcimum basilicum
dc.subjectNocicepção orofacial
dc.titleOcimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach
dc.typeArtigo


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