Artigo
Rational design of small modified peptides as ACE inhibitors
Registro en:
SILVA, D. G. et al. Rational design of small modified peptides as ACE inhibitors. Medicinal Chemistry Communications - MedChemComm, [S. l.], v. 3, p. 1290-1293, Aug. 2012.
Autor
Silva, Daniel G.
Freitas, Matheus P.
Cunha, Elaine F. F. da
Ramalho, Teodorico C.
Nunes, Cleiton A.
Institución
Resumen
Computer-assisted techniques and the strategy of combining chemical substructures were used to derive
small modified peptides as potent angiotensin-converting enzyme (ACE) inhibitors. In addition to high
potency, some of the predicted compounds are also shown to exhibit satisfactory pharmacokinetic
parameters.