Texto completo de evento
Methylene blue-mediated photoinactivation of Staphylococcus aureus assisted by gold nanoshells
Registro en:
10.1007/978-981-13-2517-5_130
0000-0002-4203-1134
Autor
FAROOQ, SAJID
CORREIA, THAMARA T. da S.
YOSHIMURA, TANIA M.
PEREIRA, SAULO de T.
RIBEIRO, MARTHA S.
ARAUJO, RENATO E.
BRAZILIAN CONGRESS ON BIOMEDICAL ENGINEERING, 26th
Resumen
Gold nanoshells (silica core/gold shell) have fascinating
optical extinction spectrum within visible to near infrared
range. In this work, we investigate the optical properties of
Au nanoshells and evaluate the feasibility of their use on
photodynamic therapy. Three dimensional finite element
simulation and experimental analyses were explored on
the assessment of the localized surface plasmon resonance
spectrum and spatial distribution of the electromagnetic
field enhancement near metallic nanoshells. In addition,
the interaction of Au nanoshells with methylene blue
(MB) photosensitizer was appraised, and 3.2???fold metal
enhanced single oxygen generation was observed. Lastly,
we investigate the effects of MB-mediated photoinactivation
on Staphylococcus aureus assisted by gold nanoshells.
The use of nanoshells on the photoinactivation
procedure reduced 3 the required illumination time for
total eradication of bacterial cells. Our results indicate that
Au nanoshells are promising candidates to enhance the
photodynamic effect on bacterial cells.