The emerging pollutants (EPs) are considered a global monitoring challenge, present in the environment in very reduced concentrations, and the proper methods for sampling and analysis are still in development. Many published types of research considering the EPs identification only depend on the analytical methodology and a more efficient higher number of EPs. The quantitative determination of the prioritized EPs in water needs advanced and ultra-sensitive instrumental techniques applied in water, water-suspended matter, soil, and biota. The regulatory framework of the water-quality parameters does not often include the microplastics, EPs, and their metabolites; especially, the groundwater water-quality monitoring and control are urgent but not yet achieved. The EPs sources in water are the sewage, industrial, and agricultural waste discard, and the UN estimated that the wastewater produced annually is about 1500 km3, about six times more water than existing in all rivers of the word. In 2015, in China, which has a fast-growing economy, the water is a scarce resource with just 8% of the world???s fresh water to meet the water needs of the 22% of the world???s population.