PEGylation of SPIONs by polycondensation reactions: A new strategy to improve colloidal stability in biological media

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorViali, Wesley Renato
dc.creatorDa Silva Nunes, Eloiza
dc.creatorDos Santos, Caio Carvalho
dc.creatorDa Silva, Sebastião William
dc.creatorAragón, Fermin Herrera
dc.creatorCoaquira, José Antonio Huamaní
dc.creatorMorais, Paulo César
dc.creatorJafelicci Júnior, Miguel
dc.date2014-05-27T11:29:57Z
dc.date2016-10-25T18:51:11Z
dc.date2014-05-27T11:29:57Z
dc.date2016-10-25T18:51:11Z
dc.date2013-07-12
dc.date.accessioned2017-04-06T02:30:59Z
dc.date.available2017-04-06T02:30:59Z
dc.identifierJournal of Nanoparticle Research, v. 15, n. 8, 2013.
dc.identifier1388-0764
dc.identifier1572-896X
dc.identifierhttp://hdl.handle.net/11449/75959
dc.identifierhttp://acervodigital.unesp.br/handle/11449/75959
dc.identifier10.1007/s11051-013-1824-x
dc.identifierWOS:000322593200021
dc.identifier2-s2.0-84879870886
dc.identifierhttp://dx.doi.org/10.1007/s11051-013-1824-x
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/896681
dc.descriptionIn this study, we report on a new route of PEGylation of superparamagnetic iron oxide nanoparticles (SPIONs) by polycondensation reaction with carboxylate groups. Structural and magnetic characterizations were performed by X-ray diffractometry (XRD), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and vibrating sample magnetometry (VSM). The XRD confirmed the spinel structure with a crystallite average diameter in the range of 3.5-4.1 nm in good agreement with the average diameter obtained by TEM (4.60-4.97 nm). The TGA data indicate the presence of PEG attached onto the SPIONs' surface. The SPIONs were superparamagnetic at room temperature with saturation magnetization (M S) from 36.7 to 54.1 emu/g. The colloidal stability of citrate- and PEG-coated SPIONs was evaluated by means of dynamic light scattering measurements as a function of pH, ionic strength, and nature of dispersion media (phosphate buffer and cell culture media). Our findings demonstrated that the PEG polymer chain length plays a key role in the coagulation behavior of the Mag-PEG suspensions. The excellent colloidal stability under the extreme conditions we evaluated, such as high ionic strength, pH near the isoelectric point, and cell culture media, revealed that suspensions comprising PEG-coated SPION, with PEG of molecular weight 600 and above, present steric stabilization attributed to the polymer chains attached onto the surface of SPIONs. © 2013 Springer Science+Business Media Dordrecht.
dc.languageeng
dc.relationJournal of Nanoparticle Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectColloidal stability
dc.subjectIron oxide
dc.subjectMagnetic fluid
dc.subjectPEG
dc.subjectSPIONs
dc.subjectSurface modification
dc.subjectColloidal Stability
dc.subjectDynamic light scattering measurement
dc.subjectMagnetic characterization
dc.subjectPolycondensation reactions
dc.subjectPolymer chain length
dc.subjectSuperparamagnetic iron oxide nanoparticles
dc.subjectVibrating sample magnetometry
dc.subjectCarboxylation
dc.subjectCell culture
dc.subjectChain length
dc.subjectIonic strength
dc.subjectIron oxides
dc.subjectMagnetic fluids
dc.subjectPlastic coatings
dc.subjectPolyethylene glycols
dc.subjectStabilization
dc.subjectSuperparamagnetism
dc.subjectSurface treatment
dc.subjectThermogravimetric analysis
dc.subjectTransmission electron microscopy
dc.subjectX ray diffraction analysis
dc.subjectSuspensions (fluids)
dc.subjectcitric acid
dc.subjectmacrogol
dc.subjectpolymer
dc.subjectsuperparamagnetic iron oxide nanoparticle
dc.subjectcell culture
dc.subjectcolloidal stability
dc.subjectdispersion
dc.subjectionic strength
dc.subjectisoelectric point
dc.subjectlight scattering
dc.subjectmagnetometry
dc.subjectmeasurement
dc.subjectmolecular weight
dc.subjectpH
dc.subjectphysical phenomena
dc.subjectpolymerization
dc.subjectpriority journal
dc.subjectroom temperature
dc.subjectthermogravimetry
dc.subjecttransmission electron microscopy
dc.subjectX ray diffraction
dc.titlePEGylation of SPIONs by polycondensation reactions: A new strategy to improve colloidal stability in biological media
dc.typeOtro


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