Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance
Los latinoamericanos muestran una ascendencia conversa generalizada y una huella de la ascendencia nativa local en la apariencia física.
dc.contributor | g.hellenthal@ucl.ac.uk; andresruiz@fudan.edu.cn | |
dc.contributor | Leverhulme Trust [F/07134/DF]; BBSRC [BB/I021213/1]; Excellence Initiative of Aix-Marseille University-A*MIDEX (a French Investissements d'Avenir programme); Wellcome Trust/Royal Society [098386/Z/12/Z]; Universidad de Antioquia (CODI sostenibilidad de grupos 2013-2014); Universidad de Antioquia (MASO 2013-2014); Conselho Nacional de Desenvolvimento Cientifico e Tecnologico; Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (Apoio a Nucleos de Excelencia Program); Fundacao de Aperfeicoamento de Pessoal de Nivel Superior; Fundacao para a Ciencia e Tecnologia (FCT) [SFRH/BPD/76207/2011]; Programa Operacional Potencial Humano (POCH) [SFRH/BPD/76207/2011]; FCT; Wellcome Trust [098051]; UCL Global Engagement Fund; Wellcome Investigator Award [WT107055AIA]; COLCIENCIAS (Colombia); Fundação para a Ciência e a Tecnologia [SFRH/BPD/76207/2011] Funding Source: FCT; BBSRC [BB/I021213/1] Funding Source: UKRI | |
dc.contributor | Barquera, Rodrigo https://orcid.org/0000-0003-0518-4518 | |
dc.contributor | Ruiz-Linares, Andres https://orcid.org/0000-0001-8372-1011 | |
dc.contributor | Amorim, Antonio https://orcid.org/0000-0002-7518-6247 | |
dc.contributor | Gusmão, Leonor https://orcid.org/0000-0003-0432-6481 | |
dc.contributor | SCHULER-FACCINI, LAVINIA https://orcid.org/0000-0002-2428-0460 | |
dc.contributor | Balding, David https://orcid.org/0000-0002-1480-6115 | |
dc.contributor | Chacon-Duque, J. Camilo https://orcid.org/0000-0003-0715-1947 | |
dc.contributor | Parolin, Maria Laura https://orcid.org/0000-0001-6726-2943 | |
dc.contributor | Resende, Carlos https://orcid.org/0000-0001-7143-7099 | |
dc.contributor | Everardo, Paola https://orcid.org/0000-0002-7629-1022 | |
dc.contributor | Sandoval, Jose https://orcid.org/0000-0003-2673-4937 | |
dc.contributor | Moral, Pedro https://orcid.org/0000-0001-5072-5892 | |
dc.contributor | Gomes, Veronica https://orcid.org/0000-0003-2815-6376 | |
dc.contributor | Salazar-Granara, Alberto https://orcid.org/0000-0003-1996-3176 | |
dc.contributor | Gomez-Valdes, Jorge Alfredo https://orcid.org/0000-0001-6996-2732 | |
dc.contributor | Sandoval, Karla https://orcid.org/0000-0002-6175-2463 | |
dc.contributor | Hunemeier, Tabita https://orcid.org/0000-0002-3156-2079 | |
dc.contributor | Mendoza-Revilla, Javier https://orcid.org/0000-0002-4026-9333 | |
dc.creator | Chacon-Duque, Juan-Camilo | |
dc.creator | Adhikari, Kaustubh | |
dc.creator | Fuentes-Guajardo, Macarena | |
dc.creator | Mendoza-Revilla, Javier | |
dc.creator | Acuna-Alonzo, Victor | |
dc.creator | Barquera, Rodrigo | |
dc.creator | Quinto-Sanchez, Mirsha | |
dc.creator | Gomez-Valdes, Jorge | |
dc.creator | Everardo Martinez, Paola | |
dc.creator | Villamil-Ramirez, Hugo | |
dc.creator | Hunemeier, Tabita | |
dc.creator | Ramallo, Virginia | |
dc.creator | Silva de Cerqueira, Caio C. | |
dc.creator | Hurtado, Malena | |
dc.creator | Villegas, Valeria | |
dc.creator | Granja, Vanessa | |
dc.creator | Villena, Mercedes | |
dc.creator | Vasquez, Rene | |
dc.creator | Llop, Elena | |
dc.creator | Sandoval, Jose R. | |
dc.creator | Salazar-Granara, Alberto A. | |
dc.creator | Parolin, Maria-Laura | |
dc.creator | Sandoval, Karla | |
dc.creator | Penaloza-Espinosa, Rosenda I. | |
dc.creator | Rangel-Villalobos, Hector | |
dc.creator | Winkler, Cheryl A. | |
dc.creator | Klitz, William | |
dc.creator | Bravi, Claudio | |
dc.creator | Molina, Julio | |
dc.creator | Corach, Daniel | |
dc.creator | Barrantes, Ramiro | |
dc.creator | Gomes, Veronica | |
dc.creator | Resende, Carlos | |
dc.creator | Gusmao, Leonor | |
dc.creator | Amorim, Antonio | |
dc.creator | Xue, Yali | |
dc.creator | Dugoujon, Jean-Michel | |
dc.creator | Moral, Pedro | |
dc.creator | Gonzalez-Jose, Rolando | |
dc.creator | Schuler-Faccini, Lavinia | |
dc.creator | Salzano, Francisco M. | |
dc.creator | Bortolini, Maria-Catira | |
dc.creator | Canizales-Quinteros, Samuel | |
dc.creator | Poletti, Giovanni | |
dc.creator | Gallo, Carla | |
dc.creator | Bedoya, Gabriel | |
dc.creator | Rothhammer, Francisco | |
dc.creator | Balding, David | |
dc.creator | Hellenthal, Garrett | |
dc.creator | Ruiz-Linares, Andres | |
dc.date | 2023-04-18T01:55:35Z | |
dc.date | 2023-04-18T01:55:35Z | |
dc.date | 2018 | |
dc.date.accessioned | 2023-09-27T20:20:56Z | |
dc.date.available | 2023-09-27T20:20:56Z | |
dc.identifier | https://repositorio.uta.cl/xmlui/handle/20.500.14396/2805 | |
dc.identifier | 2041-1723 | |
dc.identifier | 10.1038/s41467-018-07748-z | |
dc.identifier | HE9FT | |
dc.identifier | 3056824+ | |
dc.identifier | WOS:000453754200011 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8943782 | |
dc.description | Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of regional ancestry variation on physical appearance. We find that Native American ancestry components in Latin Americans correspond geographically to the present-day genetic structure of Native groups, and that sources of non-Native ancestry, and admixture timings, match documented migratory flows. We also detect South/East Mediterranean ancestry across Latin America, probably stemming mostly from the clandestine colonial migration of Christian converts of non-European origin (Conversos). Furthermore, we find that ancestry related to highland (Central Andean) versus lowland (Mapuche) Natives is associated with variation in facial features, particularly nose morphology, and detect significant differences in allele frequencies between these groups at loci previously associated with nose morphology in this sample. | |
dc.description | Los registros históricos y los análisis genéticos indican que los latinoamericanos remontan su ascendencia principalmente a la mezcla (mezcla) de nativos americanos, europeos y africanos subsaharianos. Usando nuevos métodos basados en haplotipos, aquí inferimos la ascendencia subcontinental en más de 6500 latinoamericanos y evaluamos el impacto de la variación de la ascendencia regional en la apariencia física. Encontramos que los componentes de la ascendencia nativa americana en los latinoamericanos corresponden geográficamente a la estructura genética actual de los grupos nativos, y que las fuentes de ascendencia no nativa y los tiempos de mezcla coinciden con los flujos migratorios documentados. También detectamos ascendencia del sur/este del Mediterráneo en América Latina, probablemente derivada principalmente de la migración colonial clandestina de cristianos convertidos de origen no europeo (conversos). Además, encontramos que la ascendencia relacionada con los nativos de las tierras altas (andinos centrales) versus las tierras bajas (mapuche) está asociada con la variación en los rasgos faciales, particularmente la morfología de la nariz, y detectamos diferencias significativas en las frecuencias alélicas entre estos grupos en loci previamente asociados con la morfología de la nariz en este muestra. | |
dc.format | application/pdf | |
dc.format | 13 páginas | |
dc.language | English | |
dc.publisher | NATURE PORTFOLIO | |
dc.relation | Nature Communications, vol.9 (2018) | |
dc.relation | https://doi.org/10.1038/s41467-018-07748-z | |
dc.rights | Green Submitted, Green Accepted, Green Published, gold | |
dc.rights | Acceso abierto | |
dc.source | Nature Communications | |
dc.subject | Genetic Diversity | |
dc.subject | Association Scan | |
dc.subject | Admixture | |
dc.subject | Population | |
dc.subject | Reveals | |
dc.subject | Community | |
dc.subject | Genomes | |
dc.subject | Legacy | |
dc.subject | Plink | |
dc.subject | Map | |
dc.subject | Diversidad Genética | |
dc.subject | Escaneo de Asociación | |
dc.subject | Admixtura | |
dc.subject | Población | |
dc.subject | Revela | |
dc.subject | Comunidad | |
dc.subject | Genomas | |
dc.subject | Legado | |
dc.subject | Plink | |
dc.subject | Mapa | |
dc.title | Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance | |
dc.title | Los latinoamericanos muestran una ascendencia conversa generalizada y una huella de la ascendencia nativa local en la apariencia física. | |
dc.type | Artículo de revista |