Effects of pentoxifylline and n-acetylcysteine on injuries caused by ischemia and reperfusion of splanchnic organs in rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorFreire Cerqueira, N.
dc.creatorHussni, Carlos Alberto
dc.creatorBonetti Yoshida, W.
dc.creatorSequeira, Julio Lopes
dc.creatorPadovani, C. R.
dc.date2014-05-27T11:23:48Z
dc.date2016-10-25T18:26:33Z
dc.date2014-05-27T11:23:48Z
dc.date2016-10-25T18:26:33Z
dc.date2008-12-01
dc.date.accessioned2017-04-06T01:34:26Z
dc.date.available2017-04-06T01:34:26Z
dc.identifierInternational Angiology, v. 27, n. 6, p. 512-521, 2008.
dc.identifier0392-9590
dc.identifierhttp://hdl.handle.net/11449/70802
dc.identifierhttp://acervodigital.unesp.br/handle/11449/70802
dc.identifier2-s2.0-60549094008
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/19078915
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/891869
dc.descriptionAim. Occlusion and reperfusion of splanchnic arteries cause local and systemic changes due to the release of cytotoxic substances and the interaction between neutrophils and endothelial cells. This study evaluated the role of pentoxifylline (PTX) and n-acetylcysteine (NAC) in the reduction of ischemia, reperfusion shock and associated intestinal injury. Methods. Sixty rats were divided into 6 groups of 10 animals. Rats in three groups underwent mesenteric ischemia for 30 minutes followed by 120 minutes of reperfusion, and were treated with saline (SAL-5 mL/kg/ h), pentoxifylline (PTX-50 mg/kg) or n-acetylcysteine (NAC-430 mg/kg/h). The other 3 groups underwent sham ischemia and reperfusion (I/R) and received the same treatments. Hemodynamic, biochemical and histological parameters were evaluated. Results. No significant hemodynamic or intestinal histological changes were seen in any sham group. No histological changes were found in the lung or liver of animals in the different groups. There was a progressive decrease in mean arterial blood pressure, from mean of 111.53 mmHg (30 minutes of ischemia) to 44.30±19.91 mmHg in SAL-I/R. 34.52±17.22 mmHg in PTX-I/R and 33.81±8.39 mmHg in NAC-I/R (P<0.05). In all I/R groups, there was a progressive decrease in: aortic blood flow, from median baseline of 19.00 mL/min to 2.50±5.25 mL/min in SAL-I/ R; 2.95±6.40 mL/min in PTX-I/R and 3.35±3.40 mL/min in NAC-I/R (P<0.05); in the heart rate, from mean baseline of 311.74 bpm to 233.33±83.88 bpm in SAL-I/R, 243.20±73.25 bpm in PTX-I/R and 244.92±76.05 bpm in NAC-I/R (P<0.05); and esophageal temperature, from mean baseline of 33.68°C to 30.53±2.05°C in SAL-I/R, 30.69±2.21°C in PTX-I/R and 31.43±1.03°C in NAC-I/R (P<0.05). In the other hand, there was an attenuation of mucosal damage in the small intestine of the animals receiving PTX, and only in the ileum of the animals receiving NAC. No changes were found in ileum or plasma malondialdehyde levels in any group. Conclusion. PTX was more efficient in reducing histological lesions than NAC, but neither treatment prevented hemodynamic changes during splanchnic organs I/R.
dc.languageeng
dc.relationInternational Angiology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIntestine, small
dc.subjectIschemia
dc.subjectReperfusion injury
dc.subjectShock
dc.subjectacetylcysteine
dc.subjectintercellular adhesion molecule 1
dc.subjectleukotriene B4
dc.subjectmalonaldehyde
dc.subjectpentoxifylline
dc.subjectsodium chloride
dc.subjectthromboxane A2
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectanticoagulation
dc.subjectaorta flow
dc.subjectarterial carbon dioxide tension
dc.subjectarterial oxygen tension
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectenzyme blood level
dc.subjectenzyme inhibition
dc.subjectesophagus temperature
dc.subjectheart rate
dc.subjecthematocrit
dc.subjecthemodynamics
dc.subjecthistology
dc.subjecthypoxemia
dc.subjectintestine injury
dc.subjectintestine ischemia
dc.subjectmale
dc.subjectmean arterial pressure
dc.subjectmesenteric artery occlusion
dc.subjectmetabolic acidosis
dc.subjectmucosal disease
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectrat
dc.subjectreperfusion injury
dc.subjectshock
dc.subjectsuperior mesenteric artery
dc.subjecttemperature
dc.subjecttissue level
dc.subjectvasodilatation
dc.subjectAcetylcysteine
dc.subjectAnimals
dc.subjectDisease Models, Animal
dc.subjectFree Radical Scavengers
dc.subjectHemodynamics
dc.subjectIntestinal Mucosa
dc.subjectIntestine, Small
dc.subjectMale
dc.subjectMesenteric Vascular Occlusion
dc.subjectOxidative Stress
dc.subjectPentoxifylline
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReperfusion Injury
dc.subjectSeverity of Illness Index
dc.subjectSplanchnic Circulation
dc.subjectTime Factors
dc.titleEffects of pentoxifylline and n-acetylcysteine on injuries caused by ischemia and reperfusion of splanchnic organs in rats
dc.typeOtro


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