Otro
Does cotinine act upon reactive oxygen species and peroxidases?
Registro en:
Ecletica Quimica, v. 32, n. 1, p. 65-70, 2007.
0100-4670
10.1590/S0100-46702007000100009
S0100-46702007000100009
2-s2.0-34250335024.pdf
2-s2.0-34250335024
Autor
Vellosa, J. C R
Khalil, N. M.
Fonseca, L. M.
Brunetti, Iguatemy Lourenço
Oliveira, Olga Maria Mascarenhas de Faria
Resumen
Nicotine, an oxidizing agent, is certainly one of the most widely used alkaloids in the world. It is, together with its main metabolite, cotinine, responsible for tobacco-dependence. The use of tobacco is closely associated with lung disease, morphological leukocyte modification and generation of oxidant species. The aim of this study was to look for a possible relationship between cotinine, oxidant species generation and oxidative processes. After studying the action of cotinine in some chemical oxidation models and on the enzymatic kinetics of peroxidases (myeloperoxidase and horseradish peroxidase), we concluded that cotinine does not act directly upon H 2O 2, HOCl, taurine chloramines, horseradish peroxidase or myeloperoxidase.