Missing association between telomerase activity and clinicopathological features in patients with early stage carcinoma of the cervix

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSantos-Filho, Admário S.
dc.creatorTriginelli, Sérgio Augusto
dc.creatorTraiman, Paulo
dc.creatorCunha-Melo, José Renan
dc.creatorSilva-Filho, Agnaldo L.
dc.date2014-05-27T11:22:21Z
dc.date2016-10-25T18:23:24Z
dc.date2014-05-27T11:22:21Z
dc.date2016-10-25T18:23:24Z
dc.date2007-01-01
dc.date.accessioned2017-04-06T01:23:09Z
dc.date.available2017-04-06T01:23:09Z
dc.identifierArchives of Gynecology and Obstetrics, v. 275, n. 1, p. 13-17, 2007.
dc.identifier0932-0067
dc.identifierhttp://hdl.handle.net/11449/69437
dc.identifierhttp://acervodigital.unesp.br/handle/11449/69437
dc.identifier10.1007/s00404-006-0206-3
dc.identifier2-s2.0-33751267663
dc.identifierhttp://dx.doi.org/10.1007/s00404-006-0206-3
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/890687
dc.descriptionObjectives: This study was undertaken to evaluate the association between the telomerase activity in the tumor and clinicopathological findings in patients with stage IB-IIA (FIGO) carcinoma of the cervix. Methods: Thirty-eight patients with carcinoma of the cervix submitted to radical hysterectomy were prospectively from January 1998 to November 2001. Samples from the tumor were taken and analyzed by the telomerase PCR-TRAP-ELISA kit. Clinicopathological characteristics such as age, stage, tumor size, grade of differentiation, lymphatic vascular space invasion (LVSI), parametrial involvement and status of pelvic lymph nodes were also recorded. Results: Patient's mean age was 49.3 ± 1.99 years (29-76 years). The clinical stage (FIGO) was IB in 35 patients (92.1%) and IIA in 3 patients (7.9%). The histological classification identified squamous cell carcinoma in 33 patients (86.8%) and adenocarcinoma in 5 patients (13.2%). There was no association between age, clinical stage, histological classification, tumor size, grade of differentiation and presence of LVSI with tumoral telomerase activity. The telomerase activity was not associated with the presence of vaginal involvement (P = 0.349), parametrium involvement (P = 0.916), pelvic lymph node metastasis (P = 0.988) or tumoral recurrence (P = 0.328) in patients with carcinoma of the cervix. Conclusions: Telomerase activity in the tumor is not associated with clinicopathological findings or tumor recurrence in patients with early stage cervical carcinoma. © 2006 Springer-Verlag.
dc.languageeng
dc.relationArchives of Gynecology and Obstetrics
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCarcinoma
dc.subjectCervix
dc.subjectTelomerase
dc.subjecttelomerase
dc.subjectadenocarcinoma
dc.subjectadult
dc.subjectage
dc.subjectaged
dc.subjectcancer staging
dc.subjectclinical article
dc.subjectenzyme activity
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectlymph node metastasis
dc.subjectpelvis lymph node
dc.subjectpolymerase chain reaction
dc.subjectradical hysterectomy
dc.subjectsquamous cell carcinoma
dc.subjecttelomeric repeat amplification protocol
dc.subjecttumor classification
dc.subjecttumor recurrence
dc.subjecttumor volume
dc.subjectuterine cervix carcinoma
dc.subjectAdenocarcinoma
dc.subjectAdult
dc.subjectAged
dc.subjectCarcinoma, Squamous Cell
dc.subjectFemale
dc.subjectHumans
dc.subjectLymphatic Metastasis
dc.subjectMiddle Aged
dc.subjectNeoplasm Invasiveness
dc.subjectNeoplasm Recurrence, Local
dc.subjectNeoplasm Staging
dc.subjectPrognosis
dc.subjectProspective Studies
dc.subjectTumor Markers, Biological
dc.subjectUterine Cervical Neoplasms
dc.titleMissing association between telomerase activity and clinicopathological features in patients with early stage carcinoma of the cervix
dc.typeOtro


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