Otro
Estados hiperprolactinêmicos - Inter-relações com o psiquismo
Registro en:
Revista de Psiquiatria Clinica, v. 33, n. 2, p. 68-73, 2006.
0101-6083
1806-938X
10.1590/S0101-60832006000200006
S0101-60832006000200006
2-s2.0-33747855255.pdf
2-s2.0-33747855255
Autor
Nahás, Eliana Aguiar Petri
Nahás-Neto, Jorge
Pontes, Anaglória
Dias, Rogerio
Fernandes, César Eduardo
Resumen
Hyperprolactinemia is the most frequent endocrine disorder of the hypothalamus-hypophysis axis observed in women of reproductive age. It is characterized by elevated serum prolactin levels. Prolactin production is regulated by the inhibitory action of a neurotransmitter, dopamine. Clinical manifestations include irregular menstrual cycle, amenorrhea, galactorrhea, infertility and libido decrease, but psychological symptoms, especially anxiety and depression, have also been associated with hyperprolactinemia. Nonetheless, few studies about this condition are available. In the pathogenesis of psychiatric disorders, prolactin may have either a direct action on the central nerve system or an indirect effect via gonadal hormones or function as independent factors as a result of dopamine depletion. Thus, since the prevalence of psychiatric disorders in patients with hyperprolactinemia was detected, it was concluded that further studies are necessary to investigate the basis of a potential relationship between both hyperprolactinemic and psychiatric conditions.