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Behavioral indices of moderate nigrostriatal 6–hydroxydopamine lesion: a preclinical Parkinson's model.
Asymmetries in turning and scanning were investigated in rats with different degrees of neostriatal dopamine depletion after unilateral injections of 6-hydroxydopamine into the substantia nigra. Animals with severe lesions, ...
Reinforcing properties of fencamfamine: Involvement of dopamine and opioid receptors
Fencamfamine (FCF) is a psychostimulant classified as an indirect dopamine agonist. The conditioning place preference (CPP) paradigm was used to investigate the reinforcing properties of FCF. After initial preferences had ...
Functional roles of T3.37 and S5.46 in the activation mechanism of the dopamine D1 receptor
(Springer Verlag, 2017)
© 2017, Springer-Verlag Berlin Heidelberg. The activation mechanism of dopamine receptors is unknown. The amino acids S5.42, S5.43, and S5.46 located in helix 5 appear to be crucial, but their specific roles in receptor ...
Circadian time-dependent effects of fencamfamine on inhibition of dopamine uptake and release in rat striatal slices
Fencamfamine (FCF) is a central stimulant that facilitates central dopaminergic transmission through inhibition of dopamine uptake and enhanced release of the transmitter. We evaluated the changes in the inhibition of ...
Enhancement of blood pressure response to dopamine by Angiotensin II
The interaction of dopamine and angiotensln II (AH) on blood pressure and heart rate was studied in rats. The influence of reserpine pretreatment and ragotomy was also studied. Inbred rats anesthetized with urethane received ...
Inhibition of DT-diaphorase is a requirement for Mn3+ to produce a 6-OH-dopamine like rotational behaviour
Intracerebral manganese administration together with the DT-diaphorase inhibitor dicoumarol (Mn3+ 40 nmol+-dicoumarol 2 nmol; in 4 μl) into the left medial forebrain bundle (MFB) produced a behavioural pattern characterised ...