Telomerase activity in the vaginal margins of radical hysterectomy in patients with carcinoma of the cervix: Correlation with histology and human papillomavirus

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorTriginelli, S. A.
dc.creatorSilva-Filho, A. L.
dc.creatorTraiman, Paulo
dc.creatorSilva, F. M U
dc.creatorChaves-Dias, M. C G
dc.creatorOliveira, G. C.
dc.creatorCunha-Melo, J. R.
dc.date2014-05-27T11:21:51Z
dc.date2016-10-25T18:22:08Z
dc.date2014-05-27T11:21:51Z
dc.date2016-10-25T18:22:08Z
dc.date2006-05-01
dc.date.accessioned2017-04-06T01:18:33Z
dc.date.available2017-04-06T01:18:33Z
dc.identifierInternational Journal of Gynecological Cancer, v. 16, n. 3, p. 1283-1288, 2006.
dc.identifier1048-891X
dc.identifier1525-1438
dc.identifierhttp://hdl.handle.net/11449/68865
dc.identifierhttp://acervodigital.unesp.br/handle/11449/68865
dc.identifier10.1111/j.1525-1438.2006.00400.x
dc.identifierWOS:000238255300050
dc.identifier2-s2.0-33745082373
dc.identifierhttp://dx.doi.org/10.1111/j.1525-1438.2006.00400.x
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/890177
dc.descriptionThis study was undertaken to evaluate the telomerase activity both in the tumor and in the vaginal margins of radical hysterectomy in patients with squamous cell carcinoma (SCC) of the cervix. Thirty-three patients with SCC of the cervix (study group) and 13 patients with uterine myoma (control group) were prospectively studied. Tissue samples were taken from the tumor or cervix, anterior vaginal margin (AVM), and posterior vaginal margin (PVM). The specimens were analyzed by histopathology, by a telomerase PCR-TRAP-ELISA kit, and by polymerase chain reaction using human papillomavirus (HPV) DNA. The telomerase activity was significantly higher in the tumor than in the benign cervix (P < 0.001). There was no difference in telomerase activity in the AVM and PVM in patients with cervical carcinoma compared to the control group. Telomerase activity was associated with the presence of histologic malignancy in the PVM of patients submitted to radical hysterectomy (P = 0.03). This association was not observed with the presence of HPV in AVM or PVM in the study group. Telomerase activity is a marker of histologic malignancy in patients with SCC of the cervix. There was no association between the telomerase activity and the presence of HPV in vaginal margins of patients submitted to radical hysterectomy. © 2006, Copyright the Authors.
dc.languageeng
dc.relationInternational Journal of Gynecological Cancer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCarcinoma
dc.subjectCervix
dc.subjectHPV
dc.subjectHuman papillomavirus
dc.subjectTelomerase
dc.subjecttelomerase
dc.subjectvirus DNA
dc.subjectadult
dc.subjectaged
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectenzyme activity
dc.subjectenzyme analysis
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectpolymerase chain reaction
dc.subjectpriority journal
dc.subjectsquamous cell carcinoma
dc.subjecttelomeric repeat amplification protocol
dc.subjecttissue section
dc.subjectuterine cervix carcinoma
dc.subjectuterus myoma
dc.subjectvagina
dc.subjectvaginal hysterectomy
dc.subjectWart virus
dc.subjectAdult
dc.subjectAged
dc.subjectCarcinoma, Squamous Cell
dc.subjectDNA Probes, HPV
dc.subjectFemale
dc.subjectHumans
dc.subjectHysterectomy
dc.subjectMiddle Aged
dc.subjectNeoplasm, Residual
dc.subjectPapillomaviridae
dc.subjectPolymerase Chain Reaction
dc.subjectTumor Markers, Biological
dc.subjectUterine Cervical Neoplasms
dc.subjectVagina
dc.subjectVaginal Neoplasms
dc.titleTelomerase activity in the vaginal margins of radical hysterectomy in patients with carcinoma of the cervix: Correlation with histology and human papillomavirus
dc.typeOtro


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