In vitro and in vivo models for studying Zika virus biology

dc.creatorPena, Lindomar José
dc.creatorGuarines, Klarissa Miranda
dc.creatorSilva, Anna Jéssica Duarte
dc.creatorLeal, Lígia Rosa Sales
dc.creatorFélix, Daniele Mendes
dc.creatorSilva, Adalúcia
dc.creatorOliveira, Sheilla Andrade de
dc.creatorAyres, Constância Flávia Junqueira
dc.creatorSilva Júnior, Abelardo
dc.creatorFreitas, Antonio Carlos de
dc.date2019-11-05T13:16:45Z
dc.date2019-11-05T13:16:45Z
dc.date2018
dc.date.accessioned2023-09-27T00:13:19Z
dc.date.available2023-09-27T00:13:19Z
dc.identifierPENA, Lindomar José et al. In vitro and in vivo models for studying Zika virus biology. The Journal of General Virology, v. 99, n. 12, p. 1529–1550, 2018.
dc.identifier0022-1317
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/36860
dc.identifier10.1099/jgv.0.001153
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898660
dc.descriptionThe emergence and rapid spread of Zika virus (ZIKV) in the Americas has prompted the development of in vitro and in vivo models to understand several aspects of ZIKV biology and boost the development of vaccines and antivirals. In vitro model studies include reverse genetics systems, two-dimensional (2D) cell models, such as primary cells and cell lines, and ex vivo three-dimensional (3D) models derived from skin, brain and placenta. While these models are cost-effective and allow rigorous control of experimental variables, they do not always recapitulate in vivo scenarios. Thus, a number of in vivo models have been developed, including mosquitoes (Aedes sp. and Culex sp.), embryonated chicken eggs, immunocompetent and immunodeficient mice strains, hamsters, guinea pigs, conventional swine and non-human primates. In this review, we summarize the main research systems that have been developed in recent years and discuss their advantages, limitations and main applications.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.rightsrestricted access
dc.subjectZIKV
dc.subjectAnimal models
dc.subjectEx vivo
dc.subjectIn vitro
dc.subjectIn vivo
dc.subjectAedes
dc.subjectAnimais
dc.subjectPesquisa Biomédica / métodos
dc.subjectGalinhas
dc.subjectCricetinae
dc.subjectCulex
dc.subjectModelos Animais de Doenças
dc.subjectCobaias
dc.subjectInterações Hospedeiro-Patógeno
dc.subjectCamundongos
dc.subjectModelos Teóricos
dc.subjectPrimatas
dc.subjectSuínos
dc.subjectZika virus / patogenicidade
dc.subjectZika virus / fisiologia
dc.subjectInfecção por Zika virus / patologia
dc.subjectInfecção por Zika virus / virologia
dc.titleIn vitro and in vivo models for studying Zika virus biology
dc.typeArticle


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