Aromatase and cyclooxygenase-2 expression in endometrial polyps during the menstrual cycle.

dc.creatorMaia Junior, Hugo
dc.creatorPimentel, Kleber
dc.creatorSilva, Tânia Maria Correia
dc.creatorFreitas, Luiz Antonio Rodrigues de
dc.creatorZausner, Bela
dc.creatorAthayde, Célia
dc.creatorCoutinho, Elsimar Metzker
dc.date2014-06-27T17:10:07Z
dc.date2014-06-27T17:10:07Z
dc.date2006
dc.date.accessioned2023-09-27T00:12:38Z
dc.date.available2023-09-27T00:12:38Z
dc.identifierMAIA JUNIOR, R. et al. Aromatase and cyclooxygenase-2 expression in endometrial polyps during the menstrual cycle.Aromatase and cyclooxygenase-2 expression in endometrial polyps during the menstrual cycle. Aromatase and cyclooxygenase-2 expression in endometrial polyps during the menstrual cycle. Gynecological Endocrinology, v. 22, n. 4, p. 219–224, 2006.
dc.identifier0951-3590
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7849
dc.identifier10.1080/09513590600585955
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8898557
dc.descriptionObjectives. To study the changes in aromatase, Ki-67 and cyclooxygenase-2 (COX-2) expression during the menstrual cycle in both endometrial polyps and normal endometria. Patients and methods. Paraffin-embedded tissue samples from 118 premenopausal patients were submitted to immunohistochemistry for measurement of aromatase, COX-2 and Ki-67 expression. Fifty cases of endometrial polyps and 68 cases of disease-free endometrium were included. Results. The presence of aromatase expression was significantly higher in endometrial polyps than in disease-free endometria. On the other hand, changes in COX-2 and Ki-67 expression followed a similar pattern during the menstrual cycle in both groups, expression peaking during the proliferative phase and falling during the late luteal phase. Conclusion. A significantly higher proportion of endometrial polyps express aromatase compared with disease-free endometrium; however, no correlation was found between aromatase expression and changes in either Ki-67 or COX-2 expression during the menstrual cycle.
dc.formatapplication/pdf
dc.languageeng
dc.publisherTaylor & Francis
dc.rightsopen access
dc.subjectAromatase expression
dc.subjectEndometrial polyps
dc.subjectKi-67
dc.subjectCyclooxygenase-2
dc.subjectAromatase/metabolismo
dc.subjectCiclo-Oxigenase 2/metabolismo
dc.subjectEndométrio/metabolismo
dc.subjectAntígeno Ki-67/metabolismo
dc.subjectPólipos/metabolismo
dc.subjectAdulto
dc.subjectDistribuição de Qui-Quadrado
dc.subjectEndométrio/patologia
dc.subjectFeminino
dc.subjectHumanos
dc.subjectImuno-Histoquímica
dc.subjectCiclo Menstrual/fisiologia
dc.subjectMeia-Idade
dc.subjectEstudos Retrospectivos
dc.subjectEstatísticas não Paramétricas
dc.titleAromatase and cyclooxygenase-2 expression in endometrial polyps during the menstrual cycle.
dc.typeArticle


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