Article
Immunization with newly transformed Schistosoma mansoni schistosomula tegument elicits tegument damage, reduction in egg and parasite burden
Registro en:
MELO, Tatiane Teixeira de et al. Immunization with newly transformed Schistosoma mansoni schistosomula tegument elicits tegument damage, reduction in egg and parasite burden. Parasite Immunol., v. 32, n. 11-12, p. 749-759, Nov./Dec. 2010.
0141-983
10.1111/j.1365-3024.2010.01244.x
Autor
Melo, Tatiane Teixeira de
Araújo, Juliano Michel de
Durães, Fernanda do Valle
Caliari, Marcelo Vidigal
Oliveira, Sérgio Costa
Coelho, Paulo Marcos Zach
Fonseca, Cristina Toscano
Resumen
The surface of the schistosomula is an important target for host immune system attack because the tegument represents the interface between host and parasite and thus is a poten-tial candidate for the development of new intervention strategies. In this study, we evaluated the ability of schisto-somula tegument (Smteg) to induce protection in mice. Immunization of mice with Smteg together with Freund adjuvant induced a Th1 type of immune response associated with a significant reduction in worm burden (43–48%), eggs trapped in the liver (65%), eggs eliminated in the faeces (59–60%) and granuloma number (41%). Lastly, during na in vitro study, worms from mice immunized with Smteg showed damage in the adult worm tegument and impaired egg laying