Article
The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID‑19)
Registro en:
ARCANJO, Angélica et al. The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID‑19). Scientific Reports, v. 10, p. 1-11, 2020.
2045-2322
10.1038/s41598-020-76781-0
Autor
Arcanjo, Angélica
Logullo, Jorgete
Menezes, Camilla Cristie Barreto
Giangiarulo, Thais Chrispim de Souza Carvalho
Reis, Mirella Carneiro dos
Castro, Gabriellen Menezes Migliani de
Fontes, Yasmin da Silva
Todeschini, Adriane Regina
Lima, Leonardo Freire de
Ricardo, Debora Decote
Pereira, Antônio Ferreira
Lima, Celio Geraldo Freire de
Barroso, Shana Priscila Coutinho
Takyia, Christina
Silva, Fátima Conceição
Savino, Wilson
Morrot, Alexandre
Resumen
The novel coronavirus SARS-CoV-2 causes COVID-19, a highly pathogenic viral infection threatening millions. The majority of the individuals infected are asymptomatic or mildly symptomatic showing typical clinical signs of common cold. However, approximately 20% of the patients can progress to acute respiratory distress syndrome (ARDS), evolving to death in about 5% of cases. Recently, angiotensin-converting enzyme 2 (ACE2) has been shown to be a functional receptor for virus entry into host target cells. The upregulation of ACE2 in patients with comorbidities may represent a propensity for increased viral load and spreading of infection to extrapulmonary tissues. This systemic infection is associated with higher neutrophil to lymphocyte ratio in infected tissues and high levels of pro-infammatory cytokines leading to an extensive microthrombus formation with multiorgan failure. Herein we investigated whether SARS-CoV-2 can stimulate extracellular neutrophils traps (NETs) in a process called NETosis. We demonstrated for the frst time that SARS-CoV-2 in fact is able to activate NETosis in human neutrophils. Our fndings indicated that this process is associated with increased levels of intracellular Reactive Oxygen Species (ROS) in neutrophils. The ROS-NET pathway plays a role in thrombosis formation and our study suggest the importance of this target for therapy approaches against disease.