This study reports a modified point-count method for quantifying the extent of carcinoma in prostatectomy specimens (n = 143), as adapted from Billis et al. (2003) [3]. The prostates were studied as follows: the basal/apical margins were sampled using the cone method. The remainder of the gland was divided into 12 quadrant-shaped regions that were sampled using two slices. Eight equidistant points were marked directly on the coverslip over each fragment. The points inside the tumoral areas were counted and expressed as both the percentage of prostate gland involvement by carcinoma (PGI) and the tumor volume (TV). A significant correlation between the preoperative PSA levels and each of the three quantitative estimations were observed, with improved correlations with the PGI and TV values obtained using the point-count method (viz. number of slices involved (NSI) (r = 0.32), PGI (r = 0.39) and TV (r = 0.44)). With the data sets stratified into three categories, all three methods correlated with multiple parameters, including Gleason scores ≥7, primary Gleason scores ≥4, perineural/angiolymphatic invasion, extraprostatic extension, seminal vesicle invasion and positive margins. All three quantitative methods were associated with morphologic features of tumor progression. The results obtained using this modified point-count method correlate more strongly with preoperative PSA levels.