Article
Low-level laser therapy decreases levels of lung neutrophils anti-apoptotic factors by a NF-kappaB dependent mechanism
Registro en:
AIMBIRE, F. et al. Low-level laser therapy decreases levels of lung neutrophils anti-apoptotic factors by a NF-κB dependent mechanism. International Immunopharmacology, v. 8, p. 603-605, 2008.
1567-5769
10.1016/j.intimp.2007.12.007
1878-1705
Autor
Aimbire, F.
Santos, F. V.
Albertini, R.
Faria Neto, Hugo Caire C.
Mittmann, J.
Soares, C. Pacheco
Resumen
Background and objective: Low-level laser therapy (LLLT) is a known modulator of inflammatory
process. Herein we studied the effect of 660 nm diode laser on mRNA levels of neutrophils
anti-apoptotic factors in lipopolysaccharide (LPS)-induced lung inflammation. Study design/
methodology: Mice were divided into 8 groups (n=7 for each group) and irradiated with energy
dosage of 7.5 J/cm2. The Bcl-xL and A1 mRNA levels in neutrophils were evaluated by Real Time-
PCR (RT-PCR). The animals were irradiated after exposure time of LPS. Results: LLLT and an
inhibitor of NF-κB nuclear translocation (BMS 205820) attenuated the mRNA levels of Bcl-xL
and A1 mRNA in lung neutrophils obtained from mice subjected to LPS-induced inflammation.
Conclusion: LLLT reduced the levels of anti-apoptotic factors in LPS inflamed mice lung neutrophils
by an action mechanism in which the NF-κB seems to be involved. 2025-01-01