Anti-leishmanial and immunomodulatory activities of extracts from Portulaca hirsutissima and Portulaca werdermannii.

dc.creatorCosta, José Fernando Oliveira
dc.creatorKiperstok, Alice Costa
dc.creatorDavid, Juceni Pereira de Lima
dc.creatorDavid, Jorge Mauricio
dc.creatorGiulietti, Ana Maria
dc.creatorQueiroz, Luciano Paganucci de
dc.creatorSantos, Ricardo Ribeiro dos
dc.creatorSoares, Milena Botelho Pereira
dc.date2015-04-16T18:53:26Z
dc.date2015-04-16T18:53:26Z
dc.date2007
dc.date.accessioned2023-09-26T23:52:22Z
dc.date.available2023-09-26T23:52:22Z
dc.identifierCOSTA, J. F. O. et al. Anti-leishmanial and immunomodulatory activities of extracts from Portulaca hirsutissima and Portulaca werdermannii. Fitoterapia, v. 78, n. 7-8, p. 510-514, 2007.
dc.identifier0367-326X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/10038
dc.identifier10.1016/j.fitote.2007.05.005
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8895122
dc.descriptionEthyl acetate and chloroform extracts from aerial parts of Portulaca werdermannii and P. hirsutissima were tested in lymphoproliferation assays and axenic cultures of Leishmania amazonensis and Trypanosoma cruzi. Both extracts of P. werdermannii and P. hirsutissima had a potent inhibitory activity on lymphocyte proliferation. On the contrary, only the chloroformic extract of both plants inhibited L. amazonensis growth, without effect on T. cruzi cultures. These results indicate these Portulaca species as potential sources of new active molecules for the treatment of leishmaniasis and immune-mediated pathologies
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectPortulaca werdermannii
dc.subjectPortulaca hirsutissima
dc.subjectAnti-protozoal activity
dc.subjectImmunomodulatory activity
dc.subjectAntiprotozoários/farmacologia
dc.subjectFatores Imunológicos/farmacologia
dc.subjectFitoterapia
dc.subjectExtratos Vegetais/farmacologia
dc.subjectPortulaca
dc.subjectAnimais
dc.subjectAntiprotozoários/administração & dosagem
dc.subjectAntiprotozoários/uso terapêutico
dc.subjectProliferação de Células
dc.subjectFeminino
dc.subjectFatores Imunológicos/administração & dosagem
dc.subjectConcentração Inibidora 50
dc.subjectLeishmania/efeitos de drogas
dc.subjectLeishmaniose Visceral/quimioterapia
dc.subjectLinfócitos/efeitos de drogas
dc.subjectMasculino
dc.subjectCamundongos
dc.subjectCamundongos Endogâmicos BALB C
dc.subjectTestes de Sensibilidade Parasitária
dc.subjectExtratos Vegetais/administração & dosagem
dc.subjectTrypanosoma cruzi/efeitos de drogas
dc.titleAnti-leishmanial and immunomodulatory activities of extracts from Portulaca hirsutissima and Portulaca werdermannii.
dc.typeArticle


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