The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4(+)CD103(+)CD25(negative) splenic T cell numbers.

dc.creatorAlbuquerque, Deijanira
dc.creatorNihei, Jorge Sadao
dc.creatorCardillo, Fabíola
dc.creatorSingh, Ram
dc.date2015-06-17T18:44:21Z
dc.date2015-06-17T18:44:21Z
dc.date2010
dc.date.accessioned2023-09-26T23:44:44Z
dc.date.available2023-09-26T23:44:44Z
dc.identifierALBUQUERQUE, D. et al. The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4(+)CD103(+)CD25(negative) splenic T cell numbers. Cellular Immunology, v. 260, n. 2, p. 92-97, 2010.
dc.identifier0008-8749
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/10905
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8893764
dc.descriptionIncreasing evidence implies beneficial effects of angiotensin-converting enzyme (ACE) inhibitors beyond those of their original indications to control hypertension. One of the most attractive non-hemodynamic properties of ACE inhibitors is their ability to regulate cytokine production. The mechanism(s) underlying the role of ACE inhibitors on cytokine synthesis are not well understood but they have traditionally been attributed to the inhibition of angiotensin (Ang) II formation. In fact, it has been extensively demonstrated that ACE inhibitors decrease Ang II-induced production of proinflammatory cytokines and chemokines. However, it is not well described if inhibition of endogenous Ang II generation by ACE inhibitors modulates systemic cytokine production in mice. To verify that, in this work, we investigated the effects of treatment with the ACE inhibitors enalapril and captopril on cytokine synthesis in C57Bl/6 and Balb/c mice. Our results show that enalapril up regulates IL-10 produced by splenocytes from Balb/c and C57Bl/6 mice and captopril increased it only in Balb/c mice. Furthermore, CD4(+)CD103(+) presented increased IL-10 production after enalapril treatment. Enalapril as well as captopril short-term treatment enhanced IL-2 synthesis in Balb/c mice. Besides, enhanced IL-2 and IL-10 levels correlates with increased CD4(+)CD103(+)CD25(negative) T cells numbers in spleens from enalapril-treated mice
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectACE inhibitors
dc.subjectCytokines
dc.subjectEnalapril
dc.subjectRegulatory T cells
dc.subjectCaptopril/farmacologia
dc.subjectEnalapril/farmacologia
dc.subjectCitocinas/metabolismo
dc.subjectBaço/efeitos de drogas
dc.subjectLinfócitos T/efeitos de drogas
dc.subjectInibidores da Enzima Conversora de Angiotensina/farmacologia
dc.subjectAnimais
dc.subjectAntígenos CD/metabolismo
dc.subjectCélulas Cultivadas
dc.subjectEnsaio de Imunoadsorção Enzimática
dc.subjectCitometria de Fluxo
dc.subjectCadeias alfa de Integrinas/metabolismo
dc.subjectInterleucina-10/metabolismo
dc.subjectSubunidade alfa de Receptor de Interleucina-2/metabolismo
dc.subjectCamundongos
dc.subjectCamundongos Endogâmicos BALB C
dc.subjectEspecificidade da Espécie
dc.subjectBaço/citologia
dc.subjectLinfócitos T/citologia
dc.titleThe ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4(+)CD103(+)CD25(negative) splenic T cell numbers.
dc.typeArticle


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