Article
Neurological Findings in Children without Congenital Microcephaly Exposed to Zika Virus in Utero: A Case Series Study
Registro en:
ABTIBOL-BERNARDINO, Marília Rosa et al. Neurological Findings in Children without Congenital Microcephaly Exposed to Zika Virus in Utero: A Case Series Study. Viruses, Basel, v. 12, n. 11, p. 1-14, Nov. 2020.
1999-4915
10.3390/v12111335
Autor
Abtibol-Bernardino, Marília Rosa
Peixoto, Lucíola de Fátima Albuquerque de Almeida
Almeida, Tatiane Freitas de
Otani, Rodrigo Haruo
Redivo, Elijane de Fatima
Andrade, Anny Beatriz Costa Antony de
Martinez-Espinosa, Flor Ernestina
Alecrim, Maria das Graças Costa
Castilho, Marcia da Costa
Resumen
Our thanks to collaborators who provided support in outpatient care and those who otherwise also collaborated with this project: Silmara Navarro Pennini, Ana Luisa Opromolla Pacheco, Hélio Lima Bernardino and students of the scientific initiation program. This work was supported by Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT);
and funded by Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM): Universal Amazonas),
Pro-Estado Program and POSGRAD 2020 Program; the Ministry of Health of Brazil: Programa de Pesquisa para o SUS—PPSUS and Departamento de Ciência e Tecnologia; and Leônidas and Maria Deane Institute (ILMD/Fiocruz Amazônia) in partnership with the Nacional Council for Scientific and Technological Development—CNPq The Zika virus can induce a disruptive sequence in the fetal brain and is manifested mainly by microcephaly. Knowledge gaps still exist as to whether the virus can cause minor disorders that are perceived later on during the first years of life in children who are exposed but are asymptomatic at birth. In this case series, we describe the outcomes related to neurodevelopment through the neurological assessment of 26 non-microcephalic children who had intrauterine exposure to Zika virus. Children were submitted for neurological examinations and Bayley Scales-III (cognition, language, and motor performance). The majority (65.4%) obtained satisfactory performance in neurodevelopment. The most impaired domain was language, with 30.7% impairment. Severe neurological disorders occurred in five children (19.2%) and these were spastic hemiparesis, epilepsy associated with congenital macrocephaly (Zika and human immunodeficiency virus), two cases of autism (one exposed to Zika and Toxoplasma gondii) and progressive sensorineural hearing loss (GJB2 mutation). We concluded that non-microcephalic children with intrauterine exposure to Zika virus, in their majority, had achieved satisfactory performance in all neurodevelopmental domains. One third of the
cases had some impairment, but the predominant group had mild alterations, with low occurrence of moderate to severe disorders, similar to other studies in Brazil.