Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance

dc.creatorAndrade, Bruno de Bezerril
dc.creatorReis Filho, Antonio José Souza
dc.creatorSouza Neto, Sebastião Martins
dc.creatorClarêncio, Jorge
dc.creatorCamargo, Luís Marcelo Aranha
dc.creatorBarral, Aldina Maria Prado
dc.creatorBarral Netto, Manoel
dc.date2014-03-06T17:07:42Z
dc.date2014-03-06T17:07:42Z
dc.date2010
dc.date.accessioned2023-09-26T23:37:56Z
dc.date.available2023-09-26T23:37:56Z
dc.identifierANDRADE, B. B. et al. Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance. Malaria Journal, v. 9, p.13-20, 2010.
dc.identifier1475-2875
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7377
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8892599
dc.descriptionDespite clinical descriptions of severe vivax malaria cases having been reported, data regarding immunological and inflammatory patterns are scarce. In this report, the inflammatory and immunological status of both mild and severe vivax malaria cases are compared in order to explore immunopathological events in this disease. METHODS AND RESULTS: Active and passive malaria case detections were performed during 2007 in Buritis, Rondônia, in the Brazilian Amazon. A total of 219 participants enrolled the study. Study individuals were classified according to the presence of Plasmodium vivax infection within four groups: non-infected (n = 90), asymptomatic (n = 60), mild (n = 50) and severe vivax infection (n = 19). A diagnosis of malaria was made by microscopy and molecular assays. Since at present no clear criteria define severe vivax malaria, this study adapted the consensual criteria from falciparum malaria. Patients with severe P. vivax infection were younger, had lived for shorter time in the endemic area, and recalled having experienced less previous malaria episodes than individuals with no malaria infection and with mild or asymptomatic infection. Strong linear trends were identified regarding increasing plasma levels of C reactive protein (CRP), serum creatinine, bilirubins and the graduation of disease severity. Plasma levels of tumour necrosis factor (TNF), interferon-gamma(IFN-gamma) and also IFN-gamma/interleukin-10 ratios were increased and exhibited a linear trend with gradual augmentation of disease severity. Both laboratory parameters of organ dysfunction and inflammatory cytokines were reduced during anti-parasite therapy in those patients with severe disease. CONCLUSION: Different clinical presentations of vivax malaria infection present strong association with activation of pro-inflammatory responses and cytokine imbalance. These findings are of utmost importance to improve current knowledge about physiopathological concepts of this serious widespread disease.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBioMed Central Ltd
dc.rightsopen access
dc.subjectCitocinas/sangue
dc.subjectInflamação/imunologia
dc.subjectMalária Vivax/imunologia
dc.subjectPlasmodium vivax/isolamento & purificação
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectFatores etários
dc.subjectIdoso
dc.subjectAntimaláricos/uso terapêutico
dc.subjectCitocinas/imunologia
dc.subjectCitocinas/metabolismo
dc.subjectCitometria de Fluxo
dc.subjectFeminino
dc.subjectInflamação/quimioterapia
dc.subjectHumanos
dc.subjectMalária Vivax/diagnóstico
dc.subjectMalária Vivax/quimioterapia
dc.subjectMasculino
dc.subjectMeia-Idade
dc.subjectPlasmodium vivax/imunologia
dc.subjectReação em Cadeia da Polimerase
dc.subjectÍndice de Gravidade de Doença
dc.subjectAdulto Jovem
dc.titleSevere Plasmodium vivax malaria exhibits marked inflammatory imbalance
dc.typeArticle


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