Article
Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies
Registro en:
HASLWANTER, Denise et al. Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies. Cell Host & Microbe. v. 30, p. 248-259, Feb. 2022.
1934-6069
10.1016/j.chom.2021.12.009
Autor
Haslwanter, Denise
Lasso, Gorka
Vec, Anna Z.
Furtado, Nathália Dias
Raphael, Lidiane Menezes Souza
Tse, Alexandra L.
Sun, Yan
Stransky, Stephanie
Pedreño-Lopez, Núria
Correia, Carolina Argondizo
Bornholdt, Zachary A.
Sakharkar, Mrunal
Avelino-Silva, Vivian I.
Moyer, Crystal L.
Watkins, David I.
Kallas, Esper G.
Sidoli, Simone
Walker, Laura M.
Bonaldo, Myrna C.
Chandran, Kartik
Resumen
The resurgence of yellow fever in SouthAmerica has prompted vaccination against the etiologic agent, yellow
fever virus (YFV). Current vaccines are based on a live-attenuated YF-17D virus derived from a virulent African
isolate. The capacity of these vaccines to induce neutralizing antibodies against the vaccine strain is used as
a surrogate for protection. However, the sensitivity of genetically distinct South American strains to vaccineinduced
antibodies is unknown. We show that antiviral potency of the polyclonal antibody response in vaccinees
is attenuated against an emergent Brazilian strain. This reduction was attributable to amino
acid changes at two sites in central domain II of the glycoprotein E, including multiple changes at the domain
I–domain II hinge, which are unique to and shared among most South American YFV strains. Our findings call
for a reevaluation of current approaches to YFV immunological surveillance in South America and suggest
approaches for updating vaccines.