Article
Progressive Chagas' cardiomyopathy is associated with low selenium levels
Registro en:
RIVERA, Maria Teresa et al. Progressive Chagas' cardiomyopathy is associated with low selenium levels. American Journal of Tropical Medicine and Hygiene, v. 66, n. 6, p. 706-712, 2002.
0002-9637
10.4269/ajtmh.2002.66.706
1476-1645
Autor
Rivera, Maria Teresa
Souza, Andréa P. de Souza
Hasslocher-Moreno, Alejandro Marcel
Xavier, Sergio S.
Gomes, Juliana A. S.
Rocha, Manoel Otávio C.
Correa-Oliveira, Rodrigo
Neve, Jean
Vanderpas, Jean
Araújo-Jorge, Tania C.
Resumen
Selenium (Se) deficiency is linked with some cardiomyopathies. Its status was determined in 170 patients with chronic Chagas’ disease from 2 Brazilian regions (Rio de Janeiro and Belo Horizonte), clinically stratified into groups as follows: indeterminate or asymptomatic (IND); cardiac asymptomatic (CARDa); cardiac symptomatic with moderate to severe heart dysfunction (CARDb); and healthy adults (HA), used for comparison. In most HA, Se levels were normal, excluding an overall Se deficiency. Se was significantly lower in CARDb than in HA, IND, or CARDa patients. This was not associated with a concomitant decrease in activity of glutathione peroxidase. Thyrotropin was normal, excluding iodine deficiency. Se correlated positive and significantly with ventricular ejection fraction (assessed via echocardiography). Asymptomatic children with acute Chagas’ disease had normalSe as wellas 5 noninfectious cases of cardiomyopathy. Low Se was found in 6 of 10 chagasic patients with digestive megasyndromes. Thus, the decrease in Se in chagasic patients seems to be a biological marker for Trypanosoma cruzi infection and related to the progression of pathology. 2028-12-31