Prevention of Haemophilus influenzae type b (Hib) meningitis and emergence of serotype replacement with type a strains after introduction of Hib immunization in Brazil.

Prevention of Haemophilus influenzae type b (Hib) meningitis and emergence of serotype replacement with type a strains after introduction of Hib immunization in Brazil.

dc.creatorRibeiro, Guilherme de Sousa
dc.creatorReis, Joice Neves
dc.creatorCordeiro, Soraia Machado
dc.creatorLima, Josilene Borges T
dc.creatorGouveia, Edilane Lins
dc.creatorPetersen, Maya L
dc.creatorSalgado, Kátia M
dc.creatorSilva, Hagamenon R
dc.creatorZanella, Rosemeire Cobo
dc.creatorAlmeida, Samanta C. Grassi
dc.creatorBrandileone, Maria Cristina
dc.creatorReis, Mitermayer Galvão dos
dc.creatorKo, Albert Icksang
dc.date2012-07-17T21:38:07Z
dc.date2012-07-17T21:38:07Z
dc.date2003
dc.date.accessioned2023-09-26T23:24:10Z
dc.date.available2023-09-26T23:24:10Z
dc.identifierRIBEIRO, G.S. et al. Prevention of Haemophilus influenzae type b (Hib) meningitis and emergence of serotype replacement with type a strains after introduction of Hib immunization in Brazil. Journal of Infectious Disease, v. 187, n. 1, p. 109-16, jan. 2003.
dc.identifier0022-1899
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/4177
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8890193
dc.descriptionSurveillance for Haemophilus influenzae meningitis cases was performed in Salvador, Brazil, before and after introduction of H. influenzae type b (Hib) immunization. The incidence of Hib meningitis decreased 69% during the 1-year period after initiation of Hib immunization (from 2.62 to 0.81 cases/100,000 person-years; P<.001). In contrast, the incidence for H. influenzae type a meningitis increased 8-fold (from 0.02 to 0.16 cases/100,000 person-years; P=.008). Pulsed-field gel electrophoretic analysis demonstrated that H. influenzae type a isolates belonged to 2 clonally related groups, both of which were found before Hib immunization commenced. Therefore, Hib immunization contributed to an increased risk for H. influenzae type a meningitis through selection of circulating H. influenzae type a clones. The risk attributable to serotype replacement is small in comparison to the large reduction in Hib meningitis due to immunization. However, these findings highlight the need to maintain surveillance as the use of conjugate vaccines expands worldwide.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectVacinas Anti-Haemophilus/imunologia
dc.subjectHaemophilus influenzae tipo b/classificação
dc.subjectHaemophilus influenzae/classificação
dc.subjectMeningite por Haemophilus/prevenção & controle
dc.subjectPolissacarídeos Bacterianos/imunologia
dc.subjectCapsulas Bacterianas
dc.subjectCriança
dc.subjectHaemophilus influenzae/patogenicidade
dc.subjectImunização
dc.subjectLactente
dc.subjectMeningite por Haemophilus/microbiologia
dc.subjectSorotipagem
dc.subjectVirulência
dc.titlePrevention of Haemophilus influenzae type b (Hib) meningitis and emergence of serotype replacement with type a strains after introduction of Hib immunization in Brazil.
dc.titlePrevention of Haemophilus influenzae type b (Hib) meningitis and emergence of serotype replacement with type a strains after introduction of Hib immunization in Brazil.
dc.typeArticle


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