Article
Increasing seroprevalence of human herpesvirus 8 (HHV-8) with age confirms HHV-8 endemicity in Amazon Amerindians from Brazil.
Registro en:
CUNHA, A. M. G. et al. Increasing seroprevalence of human herpesvirus 8 (HHV-8) with age confirms HHV-8 endemicity in Amazon Amerindians from Brazil. Journal of General Virology, v. 86, pt 9, p. 2433-2437, 2005.
0022-1317
10.1099/vir.0.81087-0
Autor
Cunha, Andréa Mendonça Gusmão
Araujo, Adele Caterino de
Costa, Sandra Cecilia Botelho
Fortuna, Elisabeth Santos
Boa-Sorte, Ney Cristian Amaral
Gonçalves, Marilda de Souza
Costa, Fernando Ferreira
Castro Filho, Bernardo Galvão
Resumen
Human herpesvirus 8 (HHV-8) seroprevalences were determined in two isolated Amazon
Amerindian tribes, according to age, gender and familial aggregation. Plasma and serum samples
obtained from 982 Amazon Amerindians (664 Tiriyo´ and 318 Waiampi) were tested for
antibodies against lytic and latent HHV-8 antigens by using ‘in-house’ immunofluorescence
assays. Overall, HHV-8 seroprevalence was 56?8% (57?4% in the Tiriyo´ tribe and 55?7% in
the Waiampi tribe). Seroprevalence was independent of gender and increased linearly with age:
it was 35?0% among children aged 2–9 years, 51?4% in adolescents (10–19 years), 72?9%
in adults and 82?3% in adults aged >50 years. Interestingly, 44?4% of children under 2 years
of age were HHV-8-seropositive. No significant differences in seroprevalence between tribes and
age groups were detected. It is concluded that HHV-8 is hyperendemic in Brazilian Amazon
Amerindians, with vertical and horizontal transmission during childhood, familial transmission and
sexual contact in adulthood contributing to this high prevalence in these isolated populations.