Article
Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes.
Registro en:
SANTOS, C. S. et al. Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes. Journal of Medical Microbiology, v. 59, n. 9, p. 1101–1106, 2010.
1473-5644
10.1099/jmm.0.021089-0
Autor
Santos, Cleiton Silva
Macedo, Júlio Oliveira
Bandeira, Maurício
Chagas Júnior, Adenizar Delgado das
McBride, Alan John Alexander
McBride, Flávia Weykamp da Cruz
Reis, Mitermayer Galvão dos
Athanazio, Daniel Abensur
Resumen
The mouse disease model has the advantage of a broad array of immunological and genetic tools
available for basic research. Some studies on transgenic and/or mutant mouse strains as models
for experimental leptospirosis have been reported; however, the wider use of such models is
hampered by a poor understanding of the outcome of experimental leptospiral infection among the
different mouse strains available. Here, the outcome of infection by a virulent strain of Leptospira
interrogans serogroup Icterohaemorrhagiae strain Cop was studied in four commonly used wildtype
mouse strains: A, CBA, BALB/c and C57BL/6. The end points evaluated in this study were
survival, presence of kidney lesions, leptospiral load in kidney samples, microscopic agglutination
test titre and anti-leptospiral IgG antibody levels. As expected, none of the mouse strains were
susceptible to lethal leptospirosis. However, these strains developed specific pathologies
associated with sublethal leptospirosis. The A and C57BL/6 strains exhibited a high leptospiral
load in kidney samples and the CBA and C57BL/6 strains developed severe inflammatory lesions,
whilst the BALB/c strain proved to be the most resistant to subclinical leptospirosis