Article
Frequency of the major histocompatibility complex Mamu-A*01 allele in a closed breeding colony of rhesus monkey (Macaca mulatta) from Brazil
Registro en:
ANDRADE, Márcia Cristina Ribeiro; LEITE, José Paulo Gagliardi; CABELLO, Pedro Hernan. Frequency of the major histocompatibility complex Mamu-A*01 allele in a closed breeding colony of rhesus monkey (Macaca mulatta) from Brazil. Med Primatol., v.38, p.39-41, 2009.
0047-2565
10.1111/j.1600-0684.2008.00301.x
1600-0684
Autor
Andrade, Márcia Cristina Ribeiro
Leite, José Paulo Gagliardi
Cabello, Pedro Hernan
Resumen
Rhesus monkeys are relevant models for human diseases. The simian immunodeficiency virus (SIV) infection is an useful macaque model for assessing human immunodeficiency virus (HIV) vaccine strategies. Susceptibility and resistance to viruses have been associated with particular major histocompatibility complex (MHC) molecules. Several epitopes in the HIV structural and non-structural protein restricted by distinct MHC class I haplotypes are important targets for human cytotoxic T lymphocytes, which mediate protection against SIVmac infection. Mamu-A*01, for example, is a MHC class I molecule of rhesus monkeys that presents a peptide from SIV gag protein. 2030-01-01