Longitudinal IgG antibody responses to Plasmodium vivax blood-stage antigens during and after acute vivax malaria in individuals living in the Brazilian Amazon

dc.creatorTashi, Tenzin
dc.creatorUpadhye, Aditi
dc.creatorKundu, Prasun
dc.creatorWu, Chunxiang
dc.creatorMenant, Sébastien
dc.creatorSoares, Roberta Reis
dc.creatorFerreira, Marcelo U.
dc.creatorLongley, Rhea J.
dc.creatorMueller, Ivo
dc.creatorQ. Hoang, Quyen
dc.creatorTham, Wai-Hong
dc.creatorRayner, Julian C.
dc.creatorScopel, Kézia KG
dc.creatorLima Junior, Josué C.
dc.creatorTran, Tuan M.
dc.date2023-01-17T20:03:04Z
dc.date2023-01-17T20:03:04Z
dc.date2022
dc.date.accessioned2023-09-26T22:55:43Z
dc.date.available2023-09-26T22:55:43Z
dc.identifierTASHI, Tenzin et al. Longitudinal IgG antibody responses to Plasmodium vivax blood-stage antigens during and after acute vivax malaria in individuals living in the Brazilian Amazon. PLoS Negl Trop Dis., v. 16, n. 11, e0010773, p. 1 - 16, Nov. 2022.
dc.identifier1935-2727
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/56489
dc.identifier10.1371/journal.pntd.0010773
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884859
dc.descriptionBackground To make progress towards malaria elimination, a highly effective vaccine targeting Plasmodium vivax is urgently needed. Evaluating the kinetics of natural antibody responses to vaccine candidate antigens after acute vivax malaria can inform the design of serological markers of exposure and vaccines. Methodology/Principal findings The responses of IgG antibodies to 9 P. vivax vaccine candidate antigens were evaluated in longitudinal serum samples from Brazilian individuals collected at the time of acute vivax malaria and 30, 60, and 180 days afterwards. Antigen-specific IgG correlations, seroprevalence, and half-lives were determined for each antigen using the longitudinal data. Antibody reactivities against Pv41 and PVX_081550 strongly correlated with each other at each of the four time points. The analysis identified robust responses in terms of magnitude and seroprevalence against Pv41 and PvGAMA at 30 and 60 days. Among the 8 P. vivax antigens demonstrating >50% seropositivity across all individuals, antibodies specific to PVX_081550 had the longest half-life (100 days; 95% CI, 83–130 days), followed by PvRBP2b (91 days; 95% CI, 76–110 days) and Pv12 (82 days; 95% CI, 64–110 days).
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectRespostas longitudinais de anticorpos IgG
dc.subjectAntígenos de fase sanguínea de Plasmodium vivax
dc.subjectDurante e após malária vivax aguda em indivíduos
dc.subjectVivendo na amazônia brasileira
dc.subjectLongitudinal IgG antibody responses
dc.subjectTo Plasmodium vivax blood-stage antigens
dc.subjectAfter acute vivax malaria in individuals
dc.subjectLiving in the Brazilian Amazon
dc.titleLongitudinal IgG antibody responses to Plasmodium vivax blood-stage antigens during and after acute vivax malaria in individuals living in the Brazilian Amazon
dc.typeArticle


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