Article
Three-way interactions between mosquito population, viral strain and temperature underlying chikungunya virus transmission potential
Registro en:
ZOUACHE, Karima; et al. Three-way interactions between mosquito population, viral strain and temperature underlying chikungunya virus transmission potential. Proceedings of the Royal Society B, v.281, n.1792, 9p, Oct. 2014.
0962-8452
10.1098/rspb.2014.1078
1471-2954)
Autor
Zouache, Karima
Fontaine, Albin
Vega-Rua, Anubis
Mousson, Laurence
Thiberge, Jean-Michel
Oliveira, Ricardo Lourenço de
Caro, Valérie
Lambrechts, Louis
Failloux, Anna-Bella
Resumen
Interactions between pathogens and their insect vectors in nature are under
the control of both genetic and non-genetic factors, yet most studies on
mosquito vector competence for human pathogens are conducted in laboratory
systems that do not consider genetic and/or environmental variability. Evaluating
the risk of emergence of arthropod-borne viruses (arboviruses) of public
health importance such as chikungunya virus (CHIKV) requires a more realistic
appraisal of genetic and environmental contributions to vector competence. In
particular, sources of variation do not necessarily act independently and may
combine in the form of interactions. Here, we measured CHIKV transmission
potential by the mosquito Aedes albopictus in all combinations of six worldwide
vector populations, two virus strains and two ambient temperatures (208C and
288C). Overall, CHIKV transmission potential by Ae. albopictus strongly
depended on the three-way combination of mosquito population, virus strain
and temperature. Such genotype-by-genotype-by-environment (G G E)
interactions question the relevance of vector competence studies conducted
with a simpler set of conditions. Our results highlight the need to account for
the complex interplay between vectors, pathogens and environmental factors
to accurately assess the potential of vector-borne diseases to emerge.