Article
Psycho-Neuroendocrine-Immune Interactions in COVID-19: Potential Impacts on Mental Health
Registro en:
RAONY, Ícaro et al. Psycho-Neuroendocrine-Immune Interactions in COVID-19: Potential Impacts on Mental Health. Frontiers in Immunology, v. 11, article 1170, p. 1-15, May 2020.
1664-3224
10.3389/fimmu.2020.01170
Autor
Raony, Ícaro
Figueiredo, Camila Saggioro de
Pandolfo, Pablo
Araujo, Elizabeth Giestal de
Bomfim, Priscilla Oliveira
Savino, Wilson
Resumen
Coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2). The impacts of the disease may be beyond
the respiratory system, also affecting mental health. Several factors may be involved
in the association between COVID-19 and psychiatric outcomes, such as fear inherent
in the pandemic, adverse effects of treatments, as well as financial stress, and social
isolation. Herein we discuss the growing evidence suggesting that the relationship
between SARS-CoV-2 and host may also trigger changes in brain and behavior. Based
on the similarity of SARS-CoV-2 with other coronaviruses, it is conceivable that changes
in endocrine and immune response in the periphery or in the central nervous system
may be involved in the association between SARS-CoV-2 infection and impaired mental
health. This is likely to be further enhanced, since millions of people worldwide are
isolated in quarantine to minimize the transmission of SARS-CoV-2 and social isolation
can also lead to neuroendocrine-immune changes. Accordingly, we highlight here
the hypothesis that neuroendocrine-immune interactions may be involved in negative
impacts of SARS-CoV-2 infection and social isolation on psychiatric issues.