Article
Human glutathione S-transferase polymorphisms associated with prostate cancer in the Brazilian population
Registro en:
SÁ, Renata Almeida de; et al.Human glutathione S-transferase polymorphisms associated with prostate cancer in the Brazilian population. International braz j urol, v.40, n.4, p.463-473, jul - aug. 2014.
1677-5538
10.1590/S1677-5538.IBJU.2014.04.04
Autor
Sá, Renata Almeida de
Moreyra, Aline dos Santos
Cabello, Pedro Herman
Ornellas, Antonio Augusto
Costa, Eduardo Butinhão
Matos, Cintia da Silva
Alves, Gilda
Hatagima, Ana
Resumen
Objective: To evaluate the influence of polymorphisms in GSTA1, GSTM1, GSTT1, and
GSTP1 in the risk of developing Prostate Cancer (PCa) in a population of Rio de Janeiro
and compare the distribution of allele and genotype frequencies of the polymorphisms
analyzed in the present study population with other regions in the country and different
ethnic groups.
Materials and Methods: We analyzed a sample of the Brazilian population, comprising
196 patients with PCa treated by the urology services of the Brazilian National Cancer
Institute (INCA) and Mario Kroeff Hospital (HMK), and 208 male blood donors from
the Clementino Fraga Filho Hospital, Federal University of Rio de Janeiro (UFRJ). The
polymorphisms were determined in DNA, extracted from peripheral blood leucocytes
using the Polymerase Chain Reaction and Restriction Fragment Length Polymorphism
(PCR-RFLP).
Results: Our results showed that the distribution of polymorphisms can vary significantly
according to the Brazilian region and ethnic groups. The distribution of allele
and genotype frequencies of the polymorphism GSTA1 was statistically different between
cases and controls. Genotypes (A / B + B / B) were associated with protection (OR
= 0.61, 95 % CI = 0.40-0.92) for PCa in comparison to genotype A / A.
Conclusion: The distribution of genotype frequencies of the polymorphism GSTA1 was
statistically different between the case and control groups (p = 0.023), and the presence
of genotypes A / B and B / B suggests a protective role against the risk of PCa compared
to genotype A / A. This is the first study that reports the genotypic frequency
of this polymorphism and its association with PCa in a Brazilian population sample.