Article
Normal range for fetal urine production rate customized by biometry
Registro en:
PEIXOTO-FILHO, Fernando Maia. et al. Normal range for fetal urine production rate customized by biometry. Arch. gynecol. obstet., Munchen, v. 187, n. 1, p. 31-35, 2013.
10.1007/s00404-012-2516-y
Autor
Peixoto-Filho, Fernando Maia
Sá, Renato Augusto Moreira de
Velarde, Luis Guillermo Coca
Mocarzel, Carolina de Castro
Lopes, Laudelino Marques
Ville, Yves
Resumen
Objective The aim of this study was to develop a
nomogram for fetal urine production (UPR) using
biometric parameters.
Methods A cross-sectional study was performed in 110
normal singleton fetuses with gestational ages ranging
from 20 to 40 weeks. UPR was measured using tridimensional
ultrasound (3-DUS) virtual organ computer-aided
analysis. UPR (ml/h) was calculated during the filling
phase using the equation, UPR = (VFB2-VFB1)/time.
The values for UPR were plotted as a function of fetal
biometry (femur, humerus, abdominal circumference, and
head circumference and biparietal diameter) to obtain a
nomogram for each parameter.
Results A total of 110 normal singleton fetuses with
gestational age between 20 and 40 weeks were investigated.
Five of them were excluded because the image
quality was insufficient for correct visualization of the
bladder contour. Linear regression analysis of UPR as a
function of femur, humerus, abdominal circumference, and
head circumference and biparietal diameter generated
curves that represents the normal range for UPR by
fetal biometry, and expressed by the following equations:
(1)Humerus length (HL): ln (UPR) = -5.9546 ? 0.0958 9
HL (mm); (R2 0.6422); (2) abdominal circumference:
ln (UPR) = -1.0981 ? 0.158 9 AC (mm); (R2 0.6328);
(3) femur length: ln (UPR) = -1.5133 ? 0.0803 9 FL
(mm); (R2 0.6611); (4) biparietal diameter ln (UPR) =
-7.8779 ? 0.2368 9 BPD-0.0012 9 DBP2; (R2 0.7066).
Although BPD has the highest correlation coefficient
(R2 0.7066) there was no statistical significant difference
between the parameters investigated for UPR prediction.
Conclusion The use of biometric parameters for prediction
of fetal UPR seems to be useful and can avoid the
necessity of building local nomograms for different populations.
The same strategy should be considered to other
fields in fetal medicine.