Article
Lower hookworm incidence, prevalence, and intensity of infection in children with a Bacillus Calmette-Guérin vaccination scar
Registro en:
BARRETO, M. L. et al. Lower hookworm incidence, prevalence, and intensity of infection in children with a Bacillus Calmette-Guérin vaccination scar. Journal of Infectious Disease, v. 182, n. 6, p. 1800-1803, 2000.
0022-1899
Autor
Barreto, Maurício Lima
Rodrigues, Laura Cunha
Silva, R. C.
Oliveira, Ana Marlucia de
Reis, Mitermayer Galvão dos
Santos, C. A.
Blanton, Ronald Edward
Resumen
Bacillus Calmette-Gue´rin (BCG), the most common vaccine worldwide, has broad effects on the immune system. Hookworm infections are a major source of morbidity. In response to a preliminary report of BCG vaccination protection against nematodes in human immunodeficiency
virus–infected adults, data from an ongoing prospective study were analyzed to determine the intensity (eggs per gram of stool), prevalence, and incidence of different helminths in children with and without a BCG vaccination scar. Adjusted prevalence and incidence ratios were estimated by using logistic regression. Children with a BCG vaccination scar were found to have statistically significantly lower hookwormprevalence (41%), incidence (37%), and mean egg counts (39%), after controlling for age, sex, and socioeconomic factors. There was no BCG association with incidence, prevalence, or intensity of infection with Schistosoma mansoni, Ascaris lumbricoides, or Trichuris trichiura. Such protection would have
implications for public health and for research on mechanisms behind human immunological responses to hookworm.