Article
Distribution of Human T-Lymphotropic Virus (HTLV) and Hepatitis C Co-infection in Bahia, Brazil
Registro en:
PEREIRA, Felicidade Mota et al. Distribution of Human T-Lymphotropic Virus (HTLV) and Hepatitis C Co-infection in Bahia, Brazil. Plos ONE, jul. 2020.
1932-6203
10.1371/journal.pone.0223087
Autor
Pereira, Felicidade Mota
Almeida, Maria da Conceição Chagas de
Santos, Fred Luciano Neves
Carreiro, Roberto Perez
Castro Filho, Bernardo Galvão
Grassi, Maria Fernanda Rios
Resumen
Coordination of Superior Level Staff Improvement-
Brazil (CAPES) - Finance Code 001 and National
Foundation for the Development of Private Higher
Education (FUNADESP), grants 9600140 and
9600141. Maria Fernanda R. Grassi and Bernardo
Galvão-Castro are research fellows of CNPq
(process no. 304811/2017-3 and 311054/2014-5,
respectively). Both Human T-lymphotropic virus type 1 (HTLV-1) and hepatitis C virus (HCV) are endemic in Brazil. In Salvador, the capital of the state of Bahia, 2% and 1.5% of the general population is infected with HTLV-1 or HCV. This study aimed to estimate the prevalence and the distribution of HTLV/HCV coinfection in Bahia. This cross-sectional study was conducted at the Central Laboratory of Public Health for the state of Bahia (LACEN-BA). All samples in the LACEN database submitted to serological testing for anti-HCV (chemiluminescence) and anti-HTLV-1/2 (chemiluminescence/ELISA and Western blot) from 2004 to 2013 were included. Infection rate was expressed as the number of infected individuals per 100,000 inhabitants in a given municipality; municipalities were grouped by microregion for further analysis. A total of 120,192 samples originating from 358 of the 417 municipalities in Bahia (85.8%) were evaluated. The overall HCV coinfection rate in HTLV-positive was 14.31% [2.8 (ranging from 0.4 to 8.0) per 100,000 inhabitants.] Twenty-one (5%) of the municipalities reported at least one case of HTLV/HCV coinfection. Most cases (87%) were concentrated in three microregions (Salvador: 79%, Ilhéus/Itabuna: 5%, Porto Seguro: 3%). Coinfection occurred more frequently in males (51%) with a mean age of 59 [(IQR): 46-59] years. HTLV/HCV coinfection in the state of Bahia was more frequently found among males living in the microregions of Salvador, Ilhéus/Itabuna and Porto Seguro, all of which are known to be endemic for HTLV infection.