Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients

dc.creatorMorais, Clarice Neuenschwander Lins de
dc.creatorCarvalho, Bruno de Melo
dc.creatorMelo, Wlademir Gomes de
dc.creatorMelo, Fábio Lopes de
dc.creatorLopes, Edmundo Pessoa de Almeida
dc.creatorDomingues, Ana Lúcia Coutinho
dc.creatorJucá, Norma
dc.creatorMartins, João Roberto Maciel
dc.creatorDiniz, George Tadeu Nunes
dc.creatorMontenegro, Silvia Maria Lucena
dc.date2018-04-26T12:03:44Z
dc.date2018-04-26T12:03:44Z
dc.date2010
dc.date.accessioned2023-09-26T22:44:46Z
dc.date.available2023-09-26T22:44:46Z
dc.identifierMORAIS, C. N. L. DE et al. Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients. Memorias Do Instituto Oswaldo Cruz, v. 105, n. 4, p. 460–466, jul. 2010.
dc.identifier1678-8060
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/26119
dc.identifier10.1590/S0074-02762010000400018
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8882673
dc.descriptionPAPES V/FIOCRUZ, CNPq (to SMLM)
dc.descriptionLiver biopsy is the gold-standard method to stage fibrosis; however, it is an invasive procedure and is potentially dangerous. The main objective of this study was to evaluate biological markers, such as cytokines IL-13, IFN-gamma, TNF-alpha and TGF-beta, platelets, bilirubins (Bil), alanine aminotransferase (ALT) and aspartate aminotransferase (AST), total proteins, gamma-glutamil transferase (gamma-GT) and alkaline phosphatase (AP), that could be used to predict the severity of hepatic fibrosis in schistosomiasis and hepatitis C (HC) as isolated diseases or co-infections. The following patient groups were selected: HC (n = 39), HC/hepatosplenic schistosomiasis (HSS) (n = 19), HSS (n = 22) and a control group (n = 13). ANOVA and ROC curves were used for statistical analysis. P < 0.05 was considered significant. With HC patients we showed that TNF-alpha (p = 0.020) and AP (p = 0.005) could differentiate mild and severe fibrosis. With regard to necroinflammatory activity, AST (p = 0.002), gamma-GT (p = 0.034) and AP (p = 0.001) were the best markers to differentiate mild and severe activity. In HC + HSS patients, total Bil (p = 0.008) was capable of differentiating between mild and severe fibrosis. In conclusion, our study was able to suggest biological markers that are non-invasive candidates to evaluate fibrosis and necroinflammatory activity in HC and HC + HSS.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectMarcadores biológicos
dc.subjectFibrose hepática
dc.subjectHC
dc.subjectEsquistossomose
dc.subjectBiological markers
dc.subjectHepatic fibrosis
dc.subjectHC
dc.subjectSchistosomiasis
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectAnálise de variação
dc.subjectIdoso
dc.subjectBiomarcadores / sangue
dc.subjectEstudos de caso-controle
dc.subjectHepatite C / sangue
dc.subjectHepatite C / complicações
dc.subjectHepatite C / patologia
dc.subjectHumanos
dc.subjectCirrose Hepática / sangue
dc.subjectCirrose Hepática / complicações
dc.subjectCirrose hepática / patologia
dc.subjectHepatopatias Parasitárias / sangue
dc.subjectHepatopatias Parasitárias / complicações
dc.subjectHepatopatias Parasitárias / patologia
dc.subjectMeia idade
dc.subjectNecrose / patologia
dc.subjectCurva ROC
dc.subjectEsquistossomose / sangue
dc.subjectEsquistossomose / complicações
dc.subjectEsquistossomose / patologia
dc.subjectÍndice de Gravidade da Doença
dc.subjectDoenças esplênicas / sangue
dc.subjectDoenças esplênicas / complicações
dc.subjectDoenças esplênicas / patologia
dc.subjectAdulto jovem
dc.titleCorrelation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients
dc.typeArticle


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