HPTN 063 was funded by the Division of AIDS (DAIDS), National Institute of Allergy and Infectious Disease (NIAID), National Institute on Drug Abuse (NIDA) and the National Institute of Mental Health (NIMH) under Cooperative Agreement # UM1AI068619. The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or The HIV Prevention Trials Network. The authors acknowledge the staff at the HPTN 063 study sites for their contributions to the study. Additional protocol team members include James Y. Dai, Tatiana Fernandes, Erica Hamilton, Danielle Heyl, Corey Kelly, Alex London, Jonathan Lucas, Estelle Piwowar-Manning, Agnes Nondo, Boonlure Pruenglampoo, Sarah Roberts, Regina Rocha, Susan Sherman, Harmony Waller and Louise Walshe. The authors also thank Jasper Lee for technical assistance in completing the manuscript.Successful global treatment as prevention (TasP) requires identifying HIV-positive individuals at high risk for transmitting HIV, and having impact via potential infections averted. This study estimated the frequency and predictors of numbers of HIV transmissions and bacterial sexually transmitted infection (STI) acquisition among sexually active HIV-positive individuals in care from three representative global settings.