Article
Is Leishmania (Viannia) braziliensis parasite load associated with disease pathogenesis?
Registro en:
PEREIRA, Luiza de Oliveira Ramos; et al. Is Leishmania (Viannia) braziliensis parasite load associated with disease pathogenesis?. International Journal of Infectious Diseases, v.57, p.132–137, 2017.
1201-9712
10.1016/j.ijid.2017.01.036
1878-3511
Autor
Pereira, Luiza de Oliveira Ramos
Moreira, Regina Barbosa
Oliveira, Márcia Pereira de
Reis, Soraya de Oliveira
Oliveira Neto, Manoel Paes de
Pirmez, Claude
Resumen
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Leishmania (Viannia) braziliensis is the main etiological agent of tegumentary leishmaniasis in the Americas. Parasite molecular diversity and host immune status contribute to extensive variations in its clinical presentation within endemic areas of Brazil. Pentavalent antimonials have been used for more than 60 years as the first-line drug for all cases, despite the potential for severe side effects and refractoriness. In Rio de Janeiro, Brazil, most L. (V.) braziliensis infections are benign with a scarcity of parasites, although metastasis and refractory infections can arise. In this scenario, the use of novel molecular tools can be useful for diagnosis and to assess tissue parasitism, and is of benefit to clinical and therapeutic management.