Article
The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2
Registro en:
FOO, Suan-Sin et al. The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2. Cell reports medicine, v. 2, n. 11, p. 1-25, 2021
10.1016/j.xcrm.2021.100453
Autor
Foo, Suan-Sin
Cambou, Mary Catherine
Mok, Thalia
Fajardo, Viviana M.
Jung, Kyle L.
Fuller, Trevon
Chen, Weiqiang
Kerin, Tara
Mei, Jenny
Bhattacharya, Debika
Choi, Younho
Wu, Xin
Xia, Tian
Shin, Woo-Jin
Cranston, Jessica
Aldrovandi, Grace
Tobin, Nicole
Contreras, Deisy
Ibarrondo, Francisco J.
Yang, Otto
Yang, Shangxin
Garner, Omai
Cortado, Ruth
Bryson, Yvonne
Janzen, Carla
Ghosh, Shubhamoy
Devaskar, Sherin
Asilnejad, Brenda
Moreira, Maria Elisabeth
Vasconcelos, Zilton Farias Meira de
Soni, Priya R.
Gibson, L. Caroline
Brasil, Patricia
Comhair, Suzy A. A.
Arumugaswami, Vaithilingaraja
Erzurum, Serpil C.
Rao, Rashmi
Jung, Jae U.
Nielsen-Saines, Karin
Resumen
While pregnancy increases the risk for severe COVID-19, the clinical and immunological implications of COVID-19 on maternal-fetal health remain unknown. Here, we present the clinical and immunological landscapes of 93 COVID-19 mothers and 45 of their SARS-CoV-2-exposed infants through comprehensive serum proteomics profiling for >1,400 cytokines of their peripheral and cord blood specimens. Prenatal SARS-CoV-2 infection triggers NF-κB-dependent proinflammatory immune activation. Pregnant women with severe COVID-19 show increased inflammation and unique IFN-λ antiviral signaling, with elevated levels of IFNL1 and IFNLR1. Furthermore, SARS-CoV-2 infection re-shapes maternal immunity at delivery, altering the expression of pregnancy complication-associated cytokines, inducing MMP7, MDK, and ESM1 and reducing BGN and CD209. Finally, COVID-19-exposed infants exhibit induction of T cell-associated cytokines (IL33, NFATC3, and CCL21), while some undergo IL-1β/IL-18/CASP1 axis-driven neonatal respiratory distress despite birth at term. Our findings demonstrate COVID-19-induced immune rewiring in both mothers and neonates, warranting long-term clinical follow-up to mitigate potential health risks.