Screening for severe acute respiratory syndrome coronavirus 2 in close contacts of individuals with confirmed infection: performance and operational considerations

dc.creatorZobrist, Stephanie
dc.creatorOliveira-Silva, Michelle
dc.creatorVieira, Alexia Martines
dc.creatorBansil, Pooja
dc.creatorGerth-Guyette, Emily
dc.creatorLeader, Brandon T.
dc.creatorGolden, Allison
dc.creatorSlater, Hannah
dc.creatorCruz, Catherine Duran de Lucena
dc.creatorGarbin, Eduardo
dc.creatorSagalovsky, Mariana
dc.creatorPal, Sampa
dc.creatorGupta, Vin
dc.creatorWolansky, Leo
dc.creatorDall'Acqua, Deusilene Souza Vieira
dc.creatorNaveca, Felipe Gomes
dc.creatorNascimento, Valdinete Alves do
dc.creatorVillalobos Salcedo, Juan Miguel
dc.creatorDrain, Paul K.
dc.creatorCosta, Alexandre Dias Tavares
dc.creatorDomingo, Gonzalo J.
dc.creatorPereira, Dhélio
dc.date2022-06-20T18:54:40Z
dc.date2022-06-20T18:54:40Z
dc.date2022
dc.date.accessioned2023-09-26T22:31:45Z
dc.date.available2023-09-26T22:31:45Z
dc.identifierZOBRIST, Stephanie et al. Screening for severe acute respiratory syndrome coronavirus 2 in close contacts of individuals with confirmed infection: performance and operational considerations. The Journal of Infectious Diseases, p. 1-11, 20 May 2022.
dc.identifier0022-1899
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/53379
dc.identifier10.1093/infdis/jiac204
dc.identifier1537-6613
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8880383
dc.descriptionBackground. Point-of-care and decentralized testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to inform public health responses. Performance evaluations in priority use cases such as contact tracing can highlight trade-offs in test selection and testing strategies. Methods. A prospective diagnostic accuracy study was conducted among close contacts of coronavirus disease 2019 (COVID19) cases in Brazil. Two anterior nares swabs (ANS), a nasopharyngeal swab (NPS), and saliva were collected at all visits. Vaccination history and symptoms were assessed. Household contacts were followed longitudinally. Three rapid antigen tests and 1 molecular method were evaluated for usability and performance against reference reverse-transcription polymerase chain reaction (RT-PCR) on nasopharyngeal swab specimens. Results. Fifty index cases and 214 contacts (64 household) were enrolled. Sixty-five contacts were RT-PCR positive during ≥1 visit. Vaccination did not influence viral load. Gamma variants were most prevalent; Delta variants emerged increasingly during implementation. The overall sensitivity of evaluated tests ranged from 33% to 76%. Performance was higher among symptomatic cases and those with cycle threshold (Ct) values ,34 and lower among oligosymptomatic or asymptomatic cases. Assuming a 24-hour time to results for RT-PCR, the cumulative sensitivity of an anterior nares swab rapid antigen test was .70% and almost 90% after 4 days. Conclusions. The near-immediate time to results for antigen tests significantly offsets lower analytical sensitivity in settings where RT-PCR results are delayed or unavailable.
dc.formatapplication/pdf
dc.languageeng
dc.publisherOxford University Press
dc.rightsopen access
dc.subjectPorto Velho
dc.subjectRondônia
dc.subjectAllplex SARS-CoV-2 assay
dc.subjectSalivaDirect
dc.subjectTeste PADRÃO Q COVID-19 Ag
dc.subjectLumiraDx SARS-CoV-2 Ag test
dc.subjectPorto Velho
dc.subjectRondônia
dc.subjectAllplex SARS-CoV-2 assay
dc.subjectSalivaDirect
dc.subjectSD Biosensor STANDARD Q COVID-19 Ag
dc.subjectLumiraDx SARS-CoV-2 Ag test
dc.subjectPorto Velho
dc.subjectRondônia
dc.subjectEnsayo Allplex SARS-CoV-2
dc.subjectSalivaDirect
dc.subjectSD Biosensor STANDARD Q COVID-19 Ag
dc.subjectLa Prueba LumiraDx SARS-CoV-2 Ag
dc.subjectSARS-CoV-2
dc.subjectCOVID-19
dc.subjectReação em Cadeia da Polimerase Via Transcriptase Reversa
dc.subjectKit de Reagentes para Diagnóstico
dc.titleScreening for severe acute respiratory syndrome coronavirus 2 in close contacts of individuals with confirmed infection: performance and operational considerations
dc.typeArticle


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