Article
Long-term feeding a high-fat diet causes histological and parasitological effects on murine schistosomiasis mansoni outcome
Registro en:
NEVES, Renata Heisler et al. Long-term feeding a high-fat diet causes histological and parasitological eVects on murine schistosomiasis mansoni outcome. Experimental Parasitology, v. 115, p. 324-332, 2007.
0014-4894
10.1016/j.exppara.2006.09.006
1090-2449
Autor
Neves, Renata Heisler
Alencar, Alba Cristina Miranda de Barros
Silva, Michele Costa
Aguila, Márcia Barbosa
Lacerda, Carlos Alberto Mandarim de
Silva, José Roberto Machado
Gomes, Delir Corrêa
Resumen
This study investigated whether long-term feeding a high-fat diet (HFC) has an effect on schistosomiasis mansoni outcome compared to standard chow diet (SC). Swiss Webster female mice (3 wk old) fed each diet over 5 months, and then were infected with 50 Schistosoma mansoni cercariae. Their nutritional status was assessed by monitoring growth rates twice a week and measuring serum levels of lipoproteins. Mice were euthanised 63 days after infection. Parasitological and liver histological analyses were performed. The levels of TC, HDL-C and LDL-C, fecal and tissue schistosome eggs were statistically different (p<0.05) between groups. Livers from HFC mice showed exudative, exudative/exudative-productive, exudative-productive and productive granulomas, some degree of hepatic steatosis and focal necrosis. Mice fed normal-chow did not present productive granulomas and hepatic steatosis. The morphometric evaluation of hepatic granulomas did not reach statistical significance (p>0.05) between diets assayed. The high-fat diet for long-term produces effects on schistosomiasis mansoni outcome. 2025-01-01