Article
Preinvasive and invasive disease in women with cytological diagnosis of high-grade lesion and high-grade lesion cannot exclude microinvasion.
Registro en:
KUPERMAN, Nina de Siqueira et al. Preinvasive and invasive disease in women with cytological diagnosis of high-grade lesion and high-grade lesion cannot exclude microinvasion. BMC Women's Health, London, v. 15, n. 81, 2015.
1472-6874
10.1186/s12905-015-0239-5
Autor
Kuperman, Nina de Siqueira
Russomano, Fábio Bastos
Melo, Yara Lucia Mendes Furtado de
Gomes Junior, Saint Clair dos Santos
Resumen
Background: Cervical cancer is the third most common cancer in Brazil and has a high potential for prevention
and cure. The prevalence of invasive and preinvasive disease in women with cytological diagnosis of high-grade
lesion – cannot exclude microinvasion (HSIL-micro) is not known.
Methods: This cross-sectional study used a cytology lab database to identify women with HSIL-micro and HSIL
referred to two colposcopic units from June 2006 to December 2012. For each woman with HSIL-micro, four
women with cytologic diagnosis of HSIL who met the inclusion criteria were identified. Data were obtained from
review of medical records.
Results: Forty-seven patients with report of HSIL-micro and 188 patients with report of HSIL were included.
The final diagnoses revealed a frequency of preinvasive lesions of 31.9 % (15/47) and 59.6 % (112/188) in
patients with HSIL-micro and HSIL, respectively, while the frequency of invasive disease was 63.8 % (30/47) and 11.7 %
(22/188), respectively. The HSIL-micro group showed prevalence of preinvasive or invasive disease 6.5 times greater
(95 % CI = 1.6-5.7) and, for invasive disease, 2.4 times greater (95 % CI = 1.7-3.6) than the HSIL group.
Conclusion: Higher risk of preinvasive and invasive lesions in women with cytologic diagnosis of HSIL-micro
reinforces recommendations for immediate investigation. 2016-09-30