Article
Plasma lipidome profiling of newborns with antenatal exposure to Zika virus
Registro en:
FARIA, Nieli Rodrigues da Costa et al. Plasma lipidome profiling of newborns with antenatal exposure to Zika virus. PLoS Neglected Tropical Diseases, 2021.
1935-2735
10.1371/journal.pntd.0009388
Autor
Faria, Nieli Rodrigues da Costa
Chaves Filho, Adriano Britto
Alcantara, Luiz Carlos Junior
Siqueira, Isadora Cristina de
Calcagno, Juan Ignacio
Miyamoto, Sayuri
Filippis, Ana Maria Bispo de
Yoshinaga, Marcos Yukio
Resumen
Coordenac¸ão de Vigilaˆncia em Sau´de e
Laborato´rios de Referência, Brazilian Ministry
of Health (CVSRL-Fiocruz to AMBF), Fundac¸ão
Carlos Chagas Filho de Amparo à Pesquisa do
Estado do Rio de Janeiro (FAPERJ, grant number
E-26/2002.930/2016 to AMBF), Horizon 2020
through ZikaPlan and ZikAction (grant agreement
numbers 734584 and 734857), the International
Development Research Centre Canada (IDRC,
108411-001 to AMBF), the National Council for
Scientific and Technological Development (CNPq,
440685/2016-8 and 443875/2018 to ICS), and
the São Paulo Research Foundation (FAPESP,
CEPID-Redoxoma 2013/07937–8 to SM). Postdoc
fellowships were received from the Coordination
for the Improvement of Higher Education
Personnel (MYY), IDRC (NRCF) and FAPESP
(ABC-F). The 2015–2016 Zika virus (ZIKV) outbreak in Brazil was remarkably linked to the incidence
of microcephaly and other deleterious clinical manifestations, including eye abnormalities, in
newborns. It is known that ZIKV targets the placenta, triggering an inflammatory profile that
may cause placental insufficiency. Transplacental lipid transport is delicately regulated during
pregnancy and deficiency on the delivery of lipids such as arachidonic and docosahexaenoic
acids may lead to deficits in both brain and retina during fetal development. Here,
plasma lipidome profiles of ZIKV exposed microcephalic and normocephalic newborns were
compared to non-infected controls. Our results reveal major alterations in circulating lipids
from both ZIKV exposed newborns with and without microcephaly relative to controls. In
newborns with microcephaly, the plasma concentrations of hydroxyoctadecadienoic acid
(HODE), primarily as 13-HODE isomer, derived from linoleic acid were higher as compared
to normocephalic ZIKV exposed newborns and controls. Total HODE concentrations were
also positively associated with levels of other oxidized lipids and several circulating free fatty
acids in newborns, indicating a possible plasma lipidome signature of microcephaly. Moreover,
higher concentrations of lysophosphatidylcholine in ZIKV exposed normocephalic
newborns relative to controls suggest a potential disruption of polyunsaturated fatty acids
transport across the blood-brain barrier of fetuses. The latter data is particularly important
given the neurocognitive and neurodevelopmental abnormalities observed in follow-up studies
involving children with antenatal ZIKV exposure, but normocephalic at birth. Taken
together, our data reveal that plasma lipidome alterations associated with antenatal exposure
to ZIKV could contribute to identification and monitoring of the wide spectrum of clinical
phenotypes at birth and further, during childhood.