Cryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses

dc.creatorLong, Jeffrey C
dc.creatorTaylor, Sarah E
dc.creatorBarbosa, Lucio M
dc.creatorSilva, Luciano Kalabric
dc.creatorReis, Mitermayer G
dc.creatorBlanton, Ronald E
dc.date2022-03-03T18:14:14Z
dc.date2022-03-03T18:14:14Z
dc.date2022
dc.date.accessioned2023-09-26T22:18:08Z
dc.date.available2023-09-26T22:18:08Z
dc.identifierLONG, Jeffrey C. et al. Cryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses. Scientific Reports, v. 12, n. 1059, p. 1-12, 2022.
dc.identifier2045-2322
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/51526
dc.identifier10.1038/s41598-022-04776-0
dc.identifier2045-2322
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8877542
dc.descriptionSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1038/s41598-022-04776-0.
dc.descriptionNational Institutes of Health, USA. Grant R01AI121330
dc.descriptionPatterns of diversity in pathogen genomes provide a window into the spatiotemporal spread of disease. In this study, we tested the hypothesis that Schistosoma mansoni parasites form genetic clusters that coincide with the communities of their human hosts. We also looked for genetic clustering of parasites at the sub-community level. Our data consists of 14 microsatellite DNA markers, typed from pooled DNA samples from N = 254 infected individuals living in three Brazilian communities. We found a one-to-one correspondence between genetic clusters found by K-means cluster analysis and communities when K = 3. These clusters are also easily identifed in a neighborjoining tree and principal coordinates plots. K-means analysis with K > 3 also reveals genetic clusters of parasites at the sub-community level. These sub-clusters also appear on the neighbor-joining tree and principal coordinates plots. A surprising fnding is a genetic relationship between subgroups in widely separated human communities. This connection suggests the existence of common transmission sites that have wide infuence. In summary, the genetic structure of S. mansoni in Brazil juxtaposes local isolation that is occasionally broken by long-range migration. Permanent eradication of schistosomes will require both local eforts and the identifcation of regional infection reservoirs.
dc.formatapplication/pdf
dc.languageeng
dc.publisherNature Research
dc.rightsopen access
dc.subjectEsquistossomose mansoni
dc.subjectMortalidade
dc.subjectParasitos
dc.subjectGenômica
dc.subjectSchistosomiasis mansoni
dc.subjectMortality
dc.subjectParasites
dc.subjectGenomics
dc.subjectEsquistosomiasis mansoni
dc.subjectMortalidad
dc.subjectParásitos
dc.subjectGenómica
dc.subjectSchistosomiase mansoni
dc.subjectMortalité
dc.subjectParasites
dc.subjectGénomique
dc.subjectEsquistossomose mansoni
dc.subjectMortalidade
dc.subjectParasitos
dc.subjectGenômica
dc.titleCryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses
dc.typeArticle


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