Article
Cohort-profile: Household transmission of SARS-CoV- 2 in a low-resource community in Rio de Janeiro, Brazil
Registro en:
BRASIL, Patrícia et al. Cohort-profile: Household transmission of SARS-CoV- 2 in a low-resource community in Rio de Janeiro, Brazil. BMJ Open , v.12:e067212, p. 1-7, Nov. 2022.
1756-1833
10.1136/ bmjopen-2022-067212
Autor
Brasil, Patrícia
Damasceno, Luana
Fuller, Trevon
Bastos, Leonardo S.
Cruz, Oswaldo G.
Medeiros, Fernando
Calvet, Guilherme Amaral
Resende, Paola
Whitworth, Jimmy
Smith, Chris
Siqueira, Marilda M.
Carvalho, Marilia
Resumen
Purpose To better understand the household transmission
of SARS-COV-
2
in a low-resource
community in Rio de
Janeiro during the COVID-19
pandemic (2020–2022).
Participants This is an open prospective cohort study
of children ≤12 years old and their household contacts.
During home visits over 24 months, we collected data
on sociodemographic characteristics, behavioural data,
clinical manifestations of SARS-CoV-
2,
vaccination status,
SARS-CoV-
2
(reverse transcription-polymerase
chain
reaction) RT-PCR
and anti-S
antibody tests. Among adults,
the majority of participants were women (62%).
Findings to date We enrolled 845 families from May
2020 to May 2022. The median number of residents
per household was four. The median household density,
defined as the number of persons per room, was 0.95. The
risk of SARS-CoV-
2
occurrence was higher in households
with a high number of persons per room. Children were
not the principal source of SARS-CoV-
2
infections in their
households during the first wave of the pandemic.
Future plans Future studies will investigate cellular
and humoral immune responses to locally circulating
SARS-CoV-
2
variants, which is relevant for the design of
vaccines, antivirals and monoclonal antibodies. We will
also engage in outreach to encourage vaccination as a
means of limiting the transmission of novel SARS-CoV-
2 variants and other emerging pathogens.