Article
IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system
Registro en:
FRANCA, R. F. O. et al. IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system. Journal of Neuroinflammation, v. 13, n. 1, dez. 2016.
1742-2094
10.1186/s12974-016-0628-1
Autor
Franca, Rafael F. O.
Costa, Renata S.
Silva, Jaqueline R.
Peres, Raphael S.
Mendonça, Leila R.
Colón, David F.
Alves-Filho, José Carlos
Cunha, Fernando Q.
Resumen
Viral encephalitis is a common cause of lethal infections in humans, and several different viruses are documented to be responsible. Rocio virus is a flavivirus that causes a severe lethal encephalitis syndrome in humans and also mice, providing an interesting model to study the CNS compartmentalized immune response. Interleukin 33 (IL-33), a member of the IL-1 family, is an immunomodulatory cytokine that is highly expressed in the CNS. However, the role of IL-33 on viral encephalitis remains unclear. Therefore, we aimed to explore how the IL-33/ST2 axis regulates the local immune response during Rocio virus infection.