Article
Draft genome sequences of three NDM-1-producing Enterobacteriaceae species isolated from Brazil
Registro en:
PEREIRA, Polyana Silva; et al. Draft genome sequences of three NDM-1-producing Enterobacteriaceae species isolated from Brazil. Mem Inst Oswaldo Cruz, v.110, n.4, p. 580-582, Jun. 2015.
10.1590/0074-02760150081
1678-8060
Autor
Pereira, Polyana Silva
Albano, Rodolpho Mattos
Asensi, Marise Dutra
Carvalho-Assef, Ana Paula D' A.
Resumen
The emergence of multidrug-resistant Enterobacteriaceae strains producing carbapenemases, such as NDM-1, has
become a major public health issue due to a high dissemination capacity and limited treatment options. Here we describe
the draft genome of three NDM-1-producing isolates: Providencia rettgeri (CCBH11880), Enterobacter hormaechei subsp.
oharae (CCBH10892) and Klebsiella pneumoniae (CCBH13327), isolated in Brazil. Besides blaNDM-1, resistance genes
to aminoglycosides [aadA1, aadA2, aac(6’)-Ib-cr] and quinolones (qnrA1, qnrB4) were observed which contributed to
the multidrug resistance profile. The element ISAba125 was found associated to the blaNDM-1 gene in all strains.