Preprint
Co-Infections from Zika and Chikungunya Virus in Bahia, Brazil Identified by Metagenomic Next-Generation Sequencing
Registro en:
SARDI, S. et al. Co-Infections from Zika and Chikungunya Virus in Bahia, Brazil Identified by Metagenomic Next-Generation Sequencing. Journal of Clinical Microbiology, p. 1-19, Jul. 2016.
0095-1137
10.1128/JCM.00877-16
Autor
Sardi, Silvia
Somasekar, Sneha
Naccache, Samia N.
Bandeira, Antonio Carlos de Albuquerque
Tauro, Laura Beatriz
Campos, Gubio Soares
Chiu, Charles Y.
Resumen
Metagenomic next-generation sequencing (mNGS) of 15 patients with documented ZIKV infection in Bahia, Brazil from April 2015 to January 2016 identified co-infections with chikungunya virus (CHIKV) in 2 of 15 ZIKV PCR-positive cases (13.3%). While generally non-specific, the clinical presentation corresponding to these two CHIKV/ZIKV co-infections reflected infection by the virus present at higher titer. Aside from CHIKV and ZIKV, co-infections from other viral pathogens were not detected. The mNGS approach is promsiing for differential diagnosis of acute febrile illness and identification of co-infections, although targeted arbovirus screening may be sufficient in the current ZIKV outbreak setting.