Article
Counter-Current Chromatography Separation of Isatin Derivatives using the Sandmeyer Methodology
Registro en:
ALMEIDA, Márcia R. et al. Counter-Current Chromatography Separation of Isatin Derivatives using the Sandmeyer Methodology. J. Braz. Chem. Soc., v.21, n.4, p.764-769, 2010.
0103-5053
1678-4790
Autor
Almeida, Márcia R.
Leitão, Gilda G.
Silva, Bárbara V.
Barbosa, Jussara P.
Pinto, Angelo C.
Resumen
A rapid and efficient method, using high-speed counter-current chromatography (HSCCC)
technique, was developed for the separation of isomeric isatin derivatives, prepared following the
Sandmeyer route. The biphasic solvent system composed of hexane:ethyl acetate:ethanol:water
1:0.5:0.5:1 (v/v/v/v) was used for all separations. A rapid and efficient method, using high-speed counter-current chromatography (HSCCC)
technique, was developed for the separation of isomeric isatin derivatives, prepared following the
Sandmeyer route. The biphasic solvent system composed of hexane:ethyl acetate:ethanol:water
1:0.5:0.5:1 (v/v/v/v) was used for all separations.